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Synthesis 2008(15): 2327-2332  
DOI: 10.1055/s-2008-1078598
PAPER
© Georg Thieme Verlag Stuttgart ˙ New York

A Green Reagent for the Iodination of Phenols

Y. B. Kiran, Takeo Konakahara*, Norio Sakai
Department of Pure and Applied Chemistry, Faculty of Science and Technology, Tokyo University of Science (RIKADAI), Noda, Chiba 278-8510, Japan
e-Mail: konaka@rs.noda.tus.ac.jp;
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Publikationsverlauf

Received 8 February 2008
Publikationsdatum:
17. Juli 2008 (online)

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Abstract

A new reagent (I2/NaNO2) for the iodination of the aromatic ring of phenols has been discovered. The reaction proceeds at room temperature in 1.5-6 hours. In the presence of this reagent, iodinated compounds are regioselectively formed in significant yields from the corresponding substrates.

Key words

iodination - phenols - sodium nitrite - Lewis acid - eco-friendly

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