An Efficient Synthesis of 2-Hydroxy-7,8-dihydroquinolin-5(6H)-ones and 7,8-Dihydroquinoline-2,5(1H,6H)-diones
from Morita-Baylis-Hillman Adduct Acetates

Weihui Zhong; Fuliang Lin; Ren’er Chen; Weike Su

doi:10.1055/s-2008-1078601

PAPER

An Efficient Synthesis of 2-Hydroxy-7,8-dihydroquinolin-5(6H)-ones and 7,8-Dihydroquinoline-2,5(1H,6H)-diones from Morita-Baylis-Hillman Adduct Acetates

Weihui Zhong, Fuliang Lin, Ren’er Chen, Weike Su*
College of Pharmaceutical Sciences, Zhejiang University of Technology, Zhejiang Key Laboratory of Pharmaceutical Engineering, Hangzhou 310014, P. R. of China
Fax: +86(571)88320752; e-Mail: suweike@zjut.edu.cn;

Abstract

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Abstract

A series of 2-hydroxy-7,8-dihydroquinolin-5(6H)-ones and 7,8-dihydroquinoline-2,5(1H,6H)-diones have been synthesized in good to excellent yields from Morita-Baylis-Hillman adduct acetates, cyclohexane-1,3-diones and ammonium acetate or primary amines in one pot under solvent-free conditions.

Key words

2-hydroxy-7,8-dihydroquinolin-5(6H)-ones - 7,8-dihydroquinoline-2,5(1H,6H)-diones - Morita-Baylis-Hillman adduct acetates - cyclohexane-1,3-diones - solvent-free conditions

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References

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