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DOI: 10.1055/s-2008-1078747
© Georg Thieme Verlag KG Stuttgart · New York
Choreatic Symptoms During and After Treatment with Paliperidone and Escitalopram
Publikationsverlauf
received 24.10.2007
revised 01.04.2008
accepted 04.04.2008
Publikationsdatum:
01. September 2008 (online)
Paliperidone, the first orally applicable atypical neuroleptic marketed as an extended-release preparation, is generally well tolerated [1] [5]. Over the last weeks, we have observed several young patients with schizophrenia, who showed significant akathisia during paliperidone treatment. Here we report the case of a depressed and psychotic patient who developed a dramatic choreatic syndrome during treatment with escitalopram and paliperidone.
References
- 1 Davidson M, Emsley R, Kramer M, Ford L, Pan G, Lim P, Eerdekens M. Efficacy, safety and early response of paliperidone extended-release tablets (paliperidone ER): results of a 6-week, randomized, placebo-controlled study. Schizophrenia Res. 2007; 93 117-130
- 2 Dremencov E, El Mansari M, Blier P. Distinct electrophysiological effects of paliperidone and risperidone on the firing activity of rat serotonin and norepinephrine neurons. Psychopharmacology. 2007; 194 63-72
- 3 Förstl H, Pohlmann-Eden B. Amplitudes of somatosensory evoked potentials reflect cortical hyperexcitability in antidepressant-induced myoclonus. Neurology. 1990; 40 924-926
- 4 Karlsson P, Hargarter L, Dencker E. et al . Pharmacokinetics and dopamine D2 and serotonin 5-HT2a receptor occupancy of paliperidone in healthy subjects: two open-label, single-dose studies. Pharmacopsychiatry. 2007; 40 , 227
- 5 Meltzer H, Hargarter L, Kramer M. et al . Efficacy and tolerability of oral paliperidone extended-release tablets in the treatment of acute schizophrenia: pooled data from three 6-week placebo-controlled studies. Pharmacopsychiatry. 2007; 40 , 222
- 6 Saito M, Yasui-Furukori N, Nakagami T, Furukori H, Kaneko S. Dose-dependent interaction of paroxetine with risperidone in schizophrenic patients. J Clin Psychopharmacol. 2005; 25 527-532
Correspondence
H. Förstl
Department of Psychiatry and Psychotherapy
TU Munich
Ismaningerstr. 22
81675 München
Germany
Telefon: +49/89/4140 42 00
Fax: +49/89/4140 48 37
eMail: Hans.foerstl@lrz.tu-muenchen.de