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Dtsch Med Wochenschr 2008; 133(30): 1580-1584
DOI: 10.1055/s-2008-1081115
DOI: 10.1055/s-2008-1081115
Prinzip & Perspektive | Review article
Hepatologie, Virologie
© Georg Thieme Verlag KG Stuttgart · New York
Hepatitis-C-Virus-Zellkulturmodelle
Neue Perspektiven für Forschung und KlinikHepatitis C virus cell culture modelsNew perspectives for basic science and clinicFurther Information
Publication History
eingereicht: 29.4.2008
akzeptiert: 26.6.2008
Publication Date:
18 July 2008 (online)
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Schlüsselwörter
Hepatitis C Virus - Zellkultur - Infektion - Virus
Key words
hepatitis C virus - cell culture - infection - virus
Literatur
- 1 Bartosch B, Dubuisson J, Cosset F L. Infectious hepatitis C virus pseudo-particles containing functional E1-E2 envelope protein complexes. J Exp Med. 2003; 197 633-642
- 2 Lindenbach B D, Evans M J, Syder A J. et al . Complete replication of hepatitis C virus in cell culture. Science. 2005; 309 623-626
- 3 Lohmann V, Körner F, Koch J O, Herian U, Theilmann L, Bartenschlager R. Replication of subgenomic hepatitis C virus RNAs in a hepatoma cell line. Science. 1999; 285 110-113
- 4 Manns M P, Foster G R, Rockstroh J K, Zeuzem S, Zoulim F, Houghton M. The way forward in HCV treatment – finding the right path. Nat Rev Drug Discov. 2007; 6 991-1000
- 5 Miyanari Y, Atsuzawa K, Usuda N. et al . The lipid droplet is an important organelle for hepatitis C virus production. Nat Cell Biol. 2007; 9 1089-1097
- 6 Pietschmann T, Kaul A, Koutsoudakis G. et al . Construction and characterization of infectious intragenotypic and intergenotypic hepatitis C virus chimeras. Proc Natl Acad Sci USA. 2006; 103 7408-7413
- 7 Steinmann E, Penin F, Kallis S, Patel A H, Bartenschlager R, Pietschmann T. Hepatitis C Virus p7 protein is crucial for assembly and release of infectious virions. PLoS Pathog. 2007; 3 e103
- 8 Wakita T, Pietschmann T, Kato T. et al . Production of infectious hepatitis C virus in tissue culture from a cloned viral genome. Nature Med. 2005; 11 791-796
- 9 Watashi K, Hijikata M, Hosaka M, Yamaji M, Shimotohno K. Cyclosporin A suppresses replication of hepatitis C virus genome in cultured hepatocytes. Hepatology. 2003; 38 1282-1288
- 10 Zhong J, Gastaminza P, Cheng G. et al . Robust hepatitis C virus infection in vitro. Proc Natl Acad Sci U S A. 2005; 102 9294-9299
Prof. Dr. rer. nat. Thomas Pietschmann
Twincore – Zentrum für experimentelle
und klinische Infektionsforschung, Abteilung für
experimentelle Virologie
Feodor-Lynen-Str. 7
30625 Hannover
Phone: 0511/220027-130
Fax: 0511/220027-148
Email: Pietschmann.thomas@mh-hannover.de