Planta Med 2008; 74(10): 1235-1239
DOI: 10.1055/s-2008-1081292
Pharmacology
Original Paper
© Georg Thieme Verlag KG Stuttgart · New York

Converging Effects of Ginkgo biloba Extract at the Level of Transmitter Release, NMDA and Sodium Currents and Dendritic Spikes

Bernadett K. Szasz1 , Nora Lenkey1 , Albert M. I. Barth1 , Arpad Mike1 , Zsolt Somogyvari2 , Orsolya Farkas2 , Balazs Lendvai1
  • 1Department of Pharmacology, Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest, Hungary
  • 2ASI Budapest, Hungary
Weitere Informationen

Publikationsverlauf

Received: March 3, 2008 Revised: May 20, 2008

Accepted: May 25, 2008

Publikationsdatum:
11. Juli 2008 (online)

Preview

Abstract

In this study, an attempt was made to integrate the effects of Ginkgo biloba extract (GBE) in different experimental systems (in vitro cochlea, brain slice preparations and cortical cell culture) to elucidate whether these processes converge to promote neuroprotection or interfere with normal neural function. GBE increased the release of dopamine in the cochlea. NMDA-evoked currents were dose-dependently inhibited by rapid GBE application in cultured cortical cells. GBE moderately inhibited Na+ channels at depolarised holding potential in cortical cells. These inhibitory effects by GBE may sufficiently contribute to the prevention of excitotoxic damage in neurons. However, these channels also interact with memory formation at the cellular level. The lack of effect by GBE on dendritic spike initiation in neocortical layer 5 pyramidal neurons indicates that the integrative functions may remain intact during the inhibitory actions of GBE.

Abbreviations

bAP:backpropagating action potentials

DA:dopamine

FR:fractional release

GBE:Ginkgo biloba extract

NMDA:N-methyl-d-aspartate

AS:adenine sulfate

References

Balazs Lendvai, MD, PhD

Institute of Experimental Medicine

Hungarian Academy of Sciences

Department of Pharmacology

Budapest 1083

Szigony u. 43

Hungary

Telefon: +36/1/299/1001

Fax: +36/1/210/9423

eMail: lendvai@koki.hu