(−)-Xanthienopyran, a New Inhibitor of Superoxide Anion Generation by Activated Neutrophils, and Further Constituents of the Seeds of Xanthium strumarium

Abstract

The dried seeds of Xanthium strumarium (Asteraceae) are used after thorough stir-frying as an ingredient in traditional Chinese medicines for relieving allergy. Two new compounds, xanthialdehyde (2) and (−)-xanthienopyran (7), as well as 26 known compounds were isolated in the present study. The structures of the isolates were elucidated by spectroscopic methods. Among them, compound 7 exhibited significant selective inhibition of superoxide anion generation by human neutrophils induced by formyl-L-methionyl-L-leucyl-L-phenylalanine, with an IC₅₀ value of 1.72 μg/mL.

Key words

Xanthium strumarium - Asteraceae - Cang-Er Zi - superoxide anion generation inhibitor - neutrophils

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