Planta Med 2008; 74(10): 1276-1279
DOI: 10.1055/s-2008-1081295
Natural Products Chemistry
Original Paper
© Georg Thieme Verlag KG Stuttgart · New York

(−)-Xanthienopyran, a New Inhibitor of Superoxide Anion Generation by Activated Neutrophils, and Further Constituents of the Seeds of Xanthium strumarium

Chia-Lin Lee1 , Po-Ching Huang1 , Pei-Wen Hsieh1 , Tsong-Long Hwang2 , Yu-Yi Hou3 , 4 , Fang-Rong Chang1 , Yang-Chang Wu1
  • 1Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung, Taiwan
  • 2Graduate Institute of Natural Products, Chang Gung University, Taoyuan, Taiwan
  • 3Department of Otorhinolaryngology, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan
  • 4Affiliated Hospital, Fooyin University, Kaohsiung, Taiwan
Weitere Informationen

Publikationsverlauf

Received: June 14, 2007 Revised: April 21, 2008

Accepted: May 22, 2008

Publikationsdatum:
11. Juli 2008 (online)

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Abstract

The dried seeds of Xanthium strumarium (Asteraceae) are used after thorough stir-frying as an ingredient in traditional Chinese medicines for relieving allergy. Two new compounds, xanthialdehyde (2) and (−)-xanthienopyran (7), as well as 26 known compounds were isolated in the present study. The structures of the isolates were elucidated by spectroscopic methods. Among them, compound 7 exhibited significant selective inhibition of superoxide anion generation by human neutrophils induced by formyl-L-methionyl-L-leucyl-L-phenylalanine, with an IC50 value of 1.72 μg/mL.

References

Prof. Dr. Yang-Chang Wu

Graduate Institute of Natural Products

Kaohsiung Medical University

Kaohsiung 807

Taiwan

Telefon: +886-7-312-1101 ext. 2197

Fax: +886-7-311-4773

eMail: yachwu@kmu.edu.tw

Prof. Dr. Fang-Rong Chang

Graduate Institute of Natural Products

Kaohsiung Medical University

Kaohsiung 807

Taiwan

R.O.C.

Telefon: +886-7-312-1101 ext. 2197

Fax: +886-7-311-4773

eMail: aaronfrc@kmu.edu.tw