Plant-Derived Leading Compounds for Chemotherapy of Human Immunodefiency Virus (HIV) Infection – An Update (1998 – 2007)

Paul Cos; Louis Maes; Arnold Vlietinck; Luc Pieters

doi:10.1055/s-2008-1081314

Planta Medica, Table of Contents

Planta Med 2008; 74(11): 1323-1337
DOI: 10.1055/s-2008-1081314

Pharmacology

Review
© Georg Thieme Verlag KG Stuttgart · New York

Plant-Derived Leading Compounds for Chemotherapy of Human Immunodefiency Virus (HIV) Infection – An Update (1998 – 2007)

Paul Cos¹ , Louis Maes¹ ^, ² , Arnold Vlietinck³ , Luc Pieters³

¹Laboratory of Microbiology, Parasitology and Hygiene (LMPH), Department of Pharmaceutical Sciences, University of Antwerp, Belgium
²Institute of Tropical Medicine, Antwerp, Belgium
³Laboratory of Pharmacognosy and Pharmaceutical Analysis, Department of Pharmaceutical Sciences, University of Antwerp, Belgium

Abstract

The high number of citations of the previous review on anti-HIV compounds from plants published in 1998 in Planta Medica indicates the importance of natural products research in the battle against HIV. Therefore, we have decided to write an update of our previous review paper, this time covering the time span 1998 – 2007. The following antiviral chemical classes are discussed in detail: alkaloids, carbohydrates, coumarins, flavonoids, lignans, phenolics, proteins, quinones/xanthones, tannins and terpenes. If available, chemical structures, antiviral activity and selectivity, mechanism of action, and structure-activity relationship are presented.

Key words

HIV - antiviral activity - plant-derived products - natural products - anti-HIV properties - anti-AIDS products

Full Text

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Prof. Dr. Paul Cos

Laboratory of Microbiology, Parasitology and Hygiene (LMPH)

Department of Pharmaceutical Sciences

University of Antwerp

Groenenborgerlaan 171

2020 Antwerp

Belgium

Phone: +32-3-265-3217

Email: paul.cos@ua.ac.be