Acylphenols from Myristica crassa as New Acetylcholinesterase Inhibitors

Abstract

A significant acetylcholinesterase inhibitory activity was observed for the ethyl acetate and methanol extracts from the leaves and the fruits of Myristica crassa. Three new dimeric acylphenols, giganteone C (5), maingayones B and C (6 and 7) were isolated together with the known malabaricones B and C (2 and 3) and giganteone A (4). Compounds 2 and 3 possess significant inhibitory activity on acetylcholinesterase. LC/MS study was particularly useful to discriminate structures of compounds 6 and 7.

Key words

Myristica crassa - Myristicaceae - Malabaricone - Acylphenol - Acetylcholinesterase - LC-MS

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