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DOI: 10.1055/s-2008-1081340
© Georg Thieme Verlag KG Stuttgart · New York
The in vitro Anti-Osteoporotic Activity of some Diarylheptanoids and Lignans from the Rhizomes of Dioscorea spongiosa
Publikationsverlauf
Received: March 20, 2008
Revised: May 18, 2008
Accepted: June 23, 2008
Publikationsdatum:
05. August 2008 (online)
Abstract
Three diarylheptanoids and three lignans from the 90 % ethanol fraction of the rhizomes of Dioscorea spongiosa were isolated and subjected to in vitro experiments to investigate their activity on osteoblasts and osteoclasts. Diarylheptanoid 1 and furofuran lignan 6 were found to significantly stimulate the proliferation of primary osteoblasts and 6 also mildly stimulated osteoblast mineralization by mouse calvaria osteoblastic cells. All diarylheptanoids and lignans at a concentration of 200 μM completely inhibited the formation of osteoclast-like cells. These results demonstrate that the isolated diarylheptanoids and lignans in the 90 % ethanol fraction have significant anti-osteoporotic activities.
Key words
Dioscorea spongiosa - Dioscoreaceae - Diarylheptanoids - Lignans - anti-osteoporotic activity
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- Supporting Information .
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Prof. Jun Yin
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Shenyang Pharmaceutical University
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