Frequency of the TAFI –438 G/A and factor XIIIA Val34Leu polymorphisms in patients with objectively proven pulmonary embolism

Majida Zidane; Marieke C. H. de Visser; Marije ten Wolde; Hans L.Vos; Wouter de Monyé; Rogier M. Bertina; Menno V. Huisman; the Antelope study group; on behalf of

doi:10.1160/TH03-01-0035

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 2003; 90(03): 439-445
DOI: 10.1160/TH03-01-0035

Blood Coagulation, Fibrinolysis and Cellular Haemostasis

Schattauer GmbH

Frequency of the TAFI –438 G/A and factor XIIIA Val34Leu polymorphisms in patients with objectively proven pulmonary embolism

Majida Zidane

¹Department of General Internal Medicine, Department of Hematology

,

Marieke C. H. de Visser

²Hemostasis and Thrombosis Research Center, Department of Hematology

,

Marije ten Wolde

⁴Department of Vascular Medicine, Academic Medical Center, Amsterdam, The Netherlands

,

Hans L.Vos

²Hemostasis and Thrombosis Research Center, Department of Hematology

,

Wouter de Monyé

³Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands

,

Rogier M. Bertina

²Hemostasis and Thrombosis Research Center, Department of Hematology

,

Menno V. Huisman

¹Department of General Internal Medicine, Department of Hematology

,

the Antelope study group

› Author Affiliations

Abstract

Summary

Deep vein thrombosis (DVT) and pulmonary embolism (PE) are considered to be two forms of the same disease, however it is not fully understood what determines their clinical presentation.

Proteins encoded by the FXIIIA and TAFI genes are involved in stabilizing the fibrin clot and in making it more lysis resistant. The FXIIIA 34Leu and TAFI –438A alleles might protect against DVT. Information on such an association with PE is either contradictory or missing. We hypothesized that both polymorphisms might influence the formation and fate of emboli and accordingly the risk of PE. We determined the frequencies of both polymorphisms in patients with objectively demonstrated PE.

The frequency of FXIIIA Leu34Leu in PE patients and non-PE patients was 4.5% and 8.8%, [OR 0.5 (95% CI: 0.1 to 1.9)], respectively. For –438 A/A TAFI genotype the frequency was 1.5% and 8.1% [OR 0.1 (95% CI: 0.02 to 1.1)], respectively.

Keywords

Pulmonary embolism - thrombin activatable fibrinolysis inhibitor (TAFI) / carboxypeptidases - Factor XIII / transglutaminases

Full Text

References

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