Thrombophilic mutations in high-risk atrial fibrillation patients: high prevalence of prothrombin gene G20210A polymorphism and lack of correlation with thromboembolism

Daniela Poli; Emilia Antonucci; Emanuele Cecchi; Irene Betti; Lelia Valdrè; Cristina Mugnaini; Bruno Alterini; Alessandro Morettini; Carlo Nozzoli; Rosanna Abbate; Gian Franco Gensini; Domenico Prisco

doi:10.1160/TH03-04-0240

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 2003; 90(06): 1158-1162
DOI: 10.1160/TH03-04-0240

Vascular Development and Vessel Remodelling

Schattauer GmbH

Thrombophilic mutations in high-risk atrial fibrillation patients: high prevalence of prothrombin gene G20210A polymorphism and lack of correlation with thromboembolism

Daniela Poli

⁶Dipartimento di Area Critica Medico Chirurgica, Centro Trombosi, Azienda Ospedaliera Universitaria Careggi, Florence, Italy

,

Emilia Antonucci

⁶Dipartimento di Area Critica Medico Chirurgica, Centro Trombosi, Azienda Ospedaliera Universitaria Careggi, Florence, Italy

,

Emanuele Cecchi

⁶Dipartimento di Area Critica Medico Chirurgica, Centro Trombosi, Azienda Ospedaliera Universitaria Careggi, Florence, Italy

,

Irene Betti

⁶Dipartimento di Area Critica Medico Chirurgica, Centro Trombosi, Azienda Ospedaliera Universitaria Careggi, Florence, Italy

,

Lelia Valdrè

¹Unità di Ricerca Clinica sulla Trombofilia “Marino Golinelli” U.O. di Angiologia Azienda Ospedaliera Universitaria S. Orsola-Malpighi, Bologna, Italy

,

Cristina Mugnaini

²Medicina Generale 2° Ospedale Santa Maria Annunziata, Florence, Italy

,

Bruno Alterini

³U.O. Medicina Generale 4, Azienda Ospedaliera Careggi, Florence, Italy

,

Alessandro Morettini

⁴U.O. Medicina Generale 1, Azienda Ospedaliera Careggi, Florence, Italy

,

Carlo Nozzoli

⁵U.O. Medicina Generale 2, Azienda Ospedaliera Careggi, Florence, Italy

,

Rosanna Abbate

⁶Dipartimento di Area Critica Medico Chirurgica, Centro Trombosi, Azienda Ospedaliera Universitaria Careggi, Florence, Italy

,

Gian Franco Gensini

⁶Dipartimento di Area Critica Medico Chirurgica, Centro Trombosi, Azienda Ospedaliera Universitaria Careggi, Florence, Italy

,

Domenico Prisco

⁶Dipartimento di Area Critica Medico Chirurgica, Centro Trombosi, Azienda Ospedaliera Universitaria Careggi, Florence, Italy

› Author Affiliations

Abstract

Summary

Atrial fibrillation (AF) is a common arrhythmia that results in a high risk of cerebral and peripheral embolism. Factor V Leiden and factor II G20210A variant are two leading conditions for venous thrombosis. The aim of our study was to find out whether these two common prothrombotic mutations play a role in the occurrence of embolic events in AF patients. We investigated 336 non-valvular AF patients and 336 healthy control subjects. Factor II G20210A variant was found in 24/336 patients (7.14%) and in 11/336 of control subjects (3.3%). At a multivariate analysis, factor II G20210A variant was independently associated to AF (OR 2.4 95% CI 1.1-5.2; p<0.05). No significant difference was observed in the prevalence of factor V Leiden in the two groups investigated [6/304 (2.0%) in patients vs 13/336 (3.9%) in controls (p=0.24)]. AF patients were separately analyzed in relation to the occurrence or absence of a cerebral or peripheral embolic event (200 with and 136 without embolic event). The prevalence of the two mutations among AF patients with and without an embolic event was similar [factor II G20210A polymorphism (7% and 7.3% respectively) and factor V Leiden (1.2% and 2.9%, respectively)]. No differences were found in relation to the type of embolic event. Our results suggest a possible relationship between the presence of prothrombin gene variant and AF per se.

Keywords

Atrial fibrillation - stroke - prothrombin gene - factor V Leiden

Full Text

References

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