Increased level of oxidized LDL-dependent monocytederived microparticles in acute coronary syndrome

Noriko Matsumoto; Shosaku Nomura; Hiroshi Kamihata; Yutaka Kimura; Toshiji Iwasaka

doi:10.1160/TH03-04-0247

Thrombosis and Haemostasis, Inhaltsverzeichnis

Thromb Haemost 2004; 91(01): 146-154
DOI: 10.1160/TH03-04-0247

Cell Signalling and Vessel Remodelling

Schattauer GmbH

Increased level of oxidized LDL-dependent monocytederived microparticles in acute coronary syndrome

Noriko Matsumoto

¹Second Department of Internal Medicine, Kansai Medical University, Osaka Japan

,

Shosaku Nomura

²First Department of Internal Medicine, Kansai Medical University, Osaka Japan

,

Hiroshi Kamihata

¹Second Department of Internal Medicine, Kansai Medical University, Osaka Japan

,

Yutaka Kimura

¹Second Department of Internal Medicine, Kansai Medical University, Osaka Japan

,

Toshiji Iwasaka

¹Second Department of Internal Medicine, Kansai Medical University, Osaka Japan

› Institutsangaben

Abstract

Summary

We measured and compared the levels of plasma soluble (s) Pselectin, sCD40L, platelet-derived microparticles (PDMP), monocyte-derived microparticles (MDMP), and anti-oxidized LDL antibody, to obtain a better understanding of their potential contribution to vascular complications in acute coronary syndrome (ACS). The concentrations of sP-selectin, sCD40L, PDMP, and MDMP in ACS patients were significantly higher than those in normal controls and patients with stable angina.When levels of these markers were compared with differences in concentration of anti-oxidized LDL antibody, all markers were significantly higher in ACS patients with a high level of antioxidized LDL antibody. Next, a monocytic cell line (THP-1) was incubated with high shear stress-induced platelet aggregates and PDMP. After incubation,THP-1 cells generated tissue factorexpressing MDMPs. This finding was particularly significant in the presence of oxidized LDL. These findings suggest that elevated levels of MDMPs may be a sign of atherosclerotic development in ACS patients, particularly those who exhibit anti-oxidized LDL antibodies.

Keywords

Monocyte-derived microparticle - P-selectin - acute coronary syndrome - tissue factor - anti-oxidized LDL antibody

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