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Thromb Haemost 2003; 90(03): 377-384
DOI: 10.1160/TH03-05-0268
Review Article
Schattauer GmbH

Membrane-associated CD40L and sCD40L in atherothrombotic disease

Sunil X.Anand
1   The Zena and Michael A.Weiner Cardiovascular Institute, Mount Sinai School of Medicine, New York, New York, USA
,
Juan F. Viles-Gonzalez
1   The Zena and Michael A.Weiner Cardiovascular Institute, Mount Sinai School of Medicine, New York, New York, USA
,
Juan J. Badimon
1   The Zena and Michael A.Weiner Cardiovascular Institute, Mount Sinai School of Medicine, New York, New York, USA
,
Erdal Cavusoglu
2   Department of Medicine, Division of Cardiology, SUNY Health Science Center at Brooklyn, New York, USA
,
Jonathan D. Marmur
2   Department of Medicine, Division of Cardiology, SUNY Health Science Center at Brooklyn, New York, USA
› Author Affiliations
Further Information

Publication History

Received 06 May 2003

Accepted after revision 07 July 2003

Publication Date:
05 December 2017 (online)

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Summary

Recent data suggests that CD40L is involved in the pathogenesis of atherothrombotic disease. This review will focus on the history of CD40L, its role in platelet-mediated pathogenesis of atherothrombotic disease, its association to clinical syndromes and procedures, and its role in determining plaque rupture.

Keywords

CD40L - atherothrombotic disease - platelets - extracellular matrix - matrix metalloproteinase
 

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