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Thromb Haemost 2004; 91(01): 155-161
DOI: 10.1160/TH03-05-0291
Cell Signalling and Vessel Remodelling
Schattauer GmbH

A microsatellite polymorphism in the heme oxygenase-1 gene promoter is associated with increased bilirubin and HDL levels but not with coronary artery disease

Georg Endler   *
1   Clinical Institute for Medical and Chemical Laboratory Diagnostics, University of Vienna, Medical School, Vienna, Austria
,
Markus Exner   *
1   Clinical Institute for Medical and Chemical Laboratory Diagnostics, University of Vienna, Medical School, Vienna, Austria
,
Martin Schillinger
2   Department of Internal Medicine II, Division of Angiology, University of Vienna, Medical School, Vienna, Austria
,
Rodrig Marculescu
1   Clinical Institute for Medical and Chemical Laboratory Diagnostics, University of Vienna, Medical School, Vienna, Austria
,
Raute Sunder-Plassmann
1   Clinical Institute for Medical and Chemical Laboratory Diagnostics, University of Vienna, Medical School, Vienna, Austria
,
Marianne Raith
1   Clinical Institute for Medical and Chemical Laboratory Diagnostics, University of Vienna, Medical School, Vienna, Austria
,
Nelli Jordanova
3   Department of Internal Medicine II, Division of Cardiology, University of Vienna, Medical School, Vienna, Austria
,
Johann Wojta
3   Department of Internal Medicine II, Division of Cardiology, University of Vienna, Medical School, Vienna, Austria
,
Christine Mannhalter
1   Clinical Institute for Medical and Chemical Laboratory Diagnostics, University of Vienna, Medical School, Vienna, Austria
,
Oswald F. Wagner
1   Clinical Institute for Medical and Chemical Laboratory Diagnostics, University of Vienna, Medical School, Vienna, Austria
,
Kurt Huber
4   3rd Medical Department for Cardiology and Emergency Medicine, Wilhelminenspital, Vienna, Austria
› InstitutsangabenFinancial support: This work was supported by grant #15231 of the Austrian “Fonds zur Förderung der wissenschaftlichen Forschung”
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Publikationsverlauf

Received 15. Mai 2003

Accepted after revision 08. September 2003

Publikationsdatum:
30. November 2017 (online)

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Summary

Heme oxygenase 1 (HO-1) is involved in the generation of the endogenous anti-oxidant bilirubin which exerts beneficial effects against arteriosclerosis. A (GT) repeat polymorphism in the HO-1 promoter region modulates HO-1 expression in response to oxidative stress. Recently, this polymorphism has been reported to protect from coronary artery disease in Orientals. We intended to confirm this observation in Caucasians.

We studied 649 individuals with myocardial infarction (n=258), stable coronary artery disease (n=180) and controls without coronary artery disease (n=211). Carriers of short alleles (<25 repeats) had higher bilirubin levels (median 0.66 mg/dL, IQR 0.49 to 0.91) compared to non-carriers (median 0.61mg/dL, IQR 0.45 to 0.82; p=0.03) and a more favourable lipid profile (HDL median 47mg/dL, IQR 40 to 50 vs. median 45, IQR 37 to 55, p=0.01; triglycerides median 118mg/dL, IQR 87 to 174 vs. median 132, IQR 97 to 191, p=0.03). However, no significant differences of the genotype distribution were observed between the three groups in this Caucasian study population (p=0.94).

Although potentially beneficial effects of the short HO-1 allele on lipid profile and serum bilirubin were observed, in contrast to Orientals, the HO-1 genotype was not associated with coronary artery disease in Caucasians.

Keywords

Heme oxygenase 1 - promoter polymorphism - coronary artery disease - bilirubin - Caucasians

* Georg Endler and Markus Exner contributed equally to the present paper.


 

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