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Thromb Haemost 2004; 92(02): 275-280
DOI: 10.1160/TH03-11-0720
Theme Issue Article
Schattauer GmbH

Neutrophil function in the healing wound: adding insult to injury?

Julia V. Dovi
1   Burn and Shock Trauma Institute, Department of Surgery, Loyola University Medical Center Maywood, Illinois, USA
,
Anna M. Szpaderska
1   Burn and Shock Trauma Institute, Department of Surgery, Loyola University Medical Center Maywood, Illinois, USA
,
Luisa A. DiPietro
1   Burn and Shock Trauma Institute, Department of Surgery, Loyola University Medical Center Maywood, Illinois, USA
› InstitutsangabenFinancial support: Supported by NIH GM55238 and the Dr. Ralph and Marion C. Falk Medical Research Trust.
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Publikationsverlauf

Received 26. November 2003

Accepted after revision 04. Mai 2004

Publikationsdatum:
30. November 2017 (online)

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Summary

Cells of the innate immune system, including neutrophils and macrophages, are a highly visible component of normal wound healing in adult mammals. The role of inflammatory cells in the healing wound has been widely investigated, and evidence for both positive and negative influences exists. Several recent investigations support the emerging paradigm that robust inflammation is detrimental to wound closure. This developing information suggests that the functional role of inflammatory cells in wound healing must be reevaluated.

Keywords

Wound healing - neutrophils - macrophages - inflammation
 

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