New nonlipid effects of statins and their clinical relevance in cardiovascular disease

Anetta Undas; Magdalena Celińska-Löwenhoff; Marcin Kaczor; Jacek Musial

doi:10.1160/TH04-02-0064

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 2004; 91(06): 1065-1077
DOI: 10.1160/TH04-02-0064

Review Article

Schattauer GmbH

New nonlipid effects of statins and their clinical relevance in cardiovascular disease

Anetta Undas

¹Department of Medicine, Jagiellonian University School of Medicine, Krakow, Poland

,

Magdalena Celińska-Löwenhoff

¹Department of Medicine, Jagiellonian University School of Medicine, Krakow, Poland

,

Marcin Kaczor

¹Department of Medicine, Jagiellonian University School of Medicine, Krakow, Poland

,

Jacek Musial

¹Department of Medicine, Jagiellonian University School of Medicine, Krakow, Poland

› Author Affiliations

Abstract

Summary

Inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A (HMGCoA) reductase, statins, have been demonstrated to reduce cardiovascular morbidity and mortality in patients with a wide range of cholesterol levels. Numerous cholesterol-independent effects of statins that may limit atherosclerosis are probably related to inhibition of the geranylgeranylation of GTP-binding intracellular signaling proteins and involve: improved vasoreactivity, mostly through increased NO bioavailability; decreased expression of proinflammatory cytokines (interleukin-6, interleukin-1β, tumor necrosis factor α), C-reactive protein, chemokines, matrix metalloproteinases, and tissue factor with the subsequent inhibition of thrombin generation; reduced platelet activity; increased thrombomodulin expression; enhanced fibrinolysis, regulation of angiogenesis and immunomodulation. However, the clinical relevance of multiple protective effects induced by statins has not been clarified yet.

Keywords

Statins - lipids - atherosclerosis

Full Text

References

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