Download PDF
Thromb Haemost 2004; 92(02): 227-228
DOI: 10.1160/TH04-05-0326
Editorial Focus
Schattauer GmbH

Shiga toxin-induced thrombotic microangiopathy: a thrombin-dependent process?

Phillip Tarr
1   Washington University School of Medicine, St. Louis, Missouri, USA
› Author Affiliations
Further Information

Publication History

Received 28 May 2004

Accepted 07 June 2004

Publication Date:
30 November 2017 (online)

Also available at
    Permissions and Reprints

 

 

  • References

  • 1 Raife TJ, Friedman KD, Fenwick BW. Lepirudin prevents lethal effects of shiga toxin in a canine model. Thromb Haemost 2004; 92: 387-393.
    Article in Thieme ConnectPubMedGoogle Scholar
  • 2 Chandler WL, Jelacic S, Boster DR. et al. Prothrombotic coagulation abnormalities preceding the hemolytic-uremic syndrome. N Engl J Med 2002; 346: 23-32.
    CrossrefPubMedGoogle Scholar
  • 3 Tsai HM, Chandler WL, Sarode R. et al. von Willebrand factor and von Willebrand factorcleaving metalloprotease activity in Escherichia coli O157:H7-associated hemolytic uremic syndrome. Pediatr Res 2001; 49: 653-659.
    CrossrefPubMedGoogle Scholar
  • 4 Inward CD, Howie AJ, Fitzpatrick MM. et al. Renal histopathology in fatal cases of diarrhoea-associated haemolytic uraemic syndrome. Pediatr Nephrol 1997; 11: 556-559.
    CrossrefPubMedGoogle Scholar
  • 5 Hertzke DM, Cowan LA, Schoning P. et al. Glomerular ultrastructural lesions of idiopathic cutaneous and renal glomerular vasculopathy of greyhounds. Vet Pathol 1995; 32: 451-459.
    CrossrefPubMedGoogle Scholar
  • 6 Richardson SE, Rotman TA, Jay V. et al. Experimental verocytotoxemia in rabbits. Infect Immun 1992; 60: 4154-4167.
    PubMedGoogle Scholar
  • 7 Taylor Jr FB, Tesh VL, DeBault L. et al. Characterization of the baboon responses to Shigalike toxin: descriptive study of a new primate model of toxic responses to Stx-1. Am J Pathol 1999; 154: 1285-1299.
    CrossrefPubMedGoogle Scholar
  • 8 Barrett TJ, Potter ME, Wachsmuth IK. Continuous peritoneal infusion of Shiga-like toxin II (SLT II) as a model for SLT II-induced diseases. J Infect Dis 1989; 159: 774-777.
    CrossrefPubMedGoogle Scholar
  • 9 Cunningham MA, Rondeau E, Chen X. et al. Protease-activated receptor 1 mediates thrombin-dependent, cell-mediated renal inflammation in crescentic glomerulonephritis. J Exp Med 2000; 191: 455-462.
    CrossrefPubMedGoogle Scholar
  • 10 Greinacher A, Janssens U, Berg G. et al. Lepirudin (recombinant hirudin) for parenteral anticoagulation in patients with heparin-induced thrombocytopenia. Heparin-Associated Thrombocytopenia Study (HAT) investigators. Circulation 1999; 100: 587-593.
    CrossrefPubMedGoogle Scholar
  • 11 Cornick NA, Jelacic S, Ciol MA. et al. Escherichia coli O157:H7 infections: discordance between filterable fecal Shiga toxin and disease outcome. J Infect Dis 2002; 186: 57-63.
    CrossrefPubMedGoogle Scholar