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Thromb Haemost 2005; 93(01): 124-129
DOI: 10.1160/TH04-07-0411
Platelets and Blood Cells
Schattauer GmbH

The polymorphism of platelet membrane integrin α2β1 (α2807TT) is associated with premature onset of fetal loss

Andrea Gerhardt
1   Department of Hemostasis and Transfusion Medicine, Düsseldorf, Germany
,
Rüdiger E. Scharf
1   Department of Hemostasis and Transfusion Medicine, Düsseldorf, Germany
,
Barbara Mikat-Drozdzynski
2   Department of Obstetrics and Gynecology, Heinrich Heine University Medical Center, Düsseldorf, Germany
,
Jan S. Krüssel
2   Department of Obstetrics and Gynecology, Heinrich Heine University Medical Center, Düsseldorf, Germany
,
Hans G. Bender
2   Department of Obstetrics and Gynecology, Heinrich Heine University Medical Center, Düsseldorf, Germany
,
Rainer B. Zotz
1   Department of Hemostasis and Transfusion Medicine, Düsseldorf, Germany
› Author AffiliationsFinancial support: Supported by an institutional grant (# 9772153) of the Faculty of Medicine, Heinrich Heine University, Düsseldorf
Further Information

Publication History

Received 06 July 2004

Accepted after resubmission 20 September 2004

Publication Date:
14 December 2017 (online)

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Summary

Inherited thrombophilia could increase susceptibility to adverse pregnancy outcomes such as fetal loss. We determined the G1691A mutation of the factorV gene (FVL), the G20210A mutation of the prothrombin gene, the C677T polymorphism of the methylenetetrahydrofolate-reductase (MTHFR) gene, the HPA-1 polymorphism of the β3 subunit of the platelet integrin αIIbβ3 and the C807T polymorphism of the α2 subunit of integrin α2 β1 in 104 women with fetal loss and 277 normal women. In a subgroup analysis of women with recurrent early fetal loss (n=34), the prevalence of the genetic markers did not differ significantly between the women with early fetal loss and the normal women. However, in this subgroup of patients the onset of fetal loss was significantly earlier in women with the α2807TT genotype (7.1 ± 1.9 vs. 8.8 ± 1.5 weeks, p=0.001). No such significant difference was observed in carriers of the other genetic markers. In the subgroup analysis of women with late fetal loss (n=70), only the prevalence of heterozygous FVL was significantly associated with late fetal loss (odds ratio 3.2, p=0.002). There was no significant association of any genetic risk factor with premature fetal loss in the subgroup analysis of women with at least one late miscarriage.This study demonstrates a significant association of the α2 807TT genotype of the platelet membrane integrin α2β1 with premature onset of early fetal loss. It appears that this risk factor does not induce the pathomechanism, but modulates the course of fetal loss. Furthermore, our study confirms the association of FVL with late fetal loss.

Keywords

Fetal loss - platelet receptor polymorphisms - HPA-1/PlA - αIIbβ3 - glycoprotein IIb-IIIa - α2807TT genotype - α2β1 - glycoprotein Ia-IIa
 

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