Tissue plasminogen activator in central nervous system physiology and pathology

Jerry P. Melchor; Sidney Strickland

doi:10.1160/TH04-12-0838

Thrombosis and Haemostasis, Inhaltsverzeichnis

Thromb Haemost 2005; 93(04): 655-660
DOI: 10.1160/TH04-12-0838

Theme Issue Article

Schattauer GmbH

Tissue plasminogen activator in central nervous system physiology and pathology

Jerry P. Melchor

¹Laboratory of Neurobiology and Genetics, The Rockefeller University, New York, New York, USA

,

Sidney Strickland

¹Laboratory of Neurobiology and Genetics, The Rockefeller University, New York, New York, USA

› Institutsangaben

Abstract

Summary

Although conventionally associated with fibrin clot degradation, recent work has uncovered new functions for the tissue plasminogen activator (tPA)/plasminogen cascade in central nervous system physiology and pathology. This extracellular proteolytic cascade has been shown to have roles in learning and memory, stress, neuronal degeneration, addiction and Alzheimer’s disease. The current review considers the different ways tPA functions in the brain.

Keywords

Tissue-type plasminogen activator - plasminogen - central nervous system - LTP - excitotoxicity

Volltext

Referenzen

References
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