Preoperative fibrin monomer measurement allows risk stratification for high intraoperative blood loss in elective surgery

Wolfgang Korte; Konrad Gabi; Mirjam Rohner; Anita Gähler; Christine Szadkowski; Thomas W. Schnider; Jochen Lange; Walter Riesen

doi:10.1160/TH05-01-0028

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 2005; 94(01): 211-215
DOI: 10.1160/TH05-01-0028

New Technologies and Diagnostic Tools

Schattauer GmbH

Preoperative fibrin monomer measurement allows risk stratification for high intraoperative blood loss in elective surgery

Authors

Wolfgang Korte

¹Institute for Clinical Chemistry and Haematology
Konrad Gabi

²Institute for Anaesthesiology
Mirjam Rohner

¹Institute for Clinical Chemistry and Haematology
Anita Gähler

¹Institute for Clinical Chemistry and Haematology
Christine Szadkowski

²Institute for Anaesthesiology
Thomas W. Schnider

²Institute for Anaesthesiology
Jochen Lange

³Department of Surgery, Kantonsspital, Gallen, Switzerland
Walter Riesen

¹Institute for Clinical Chemistry and Haematology

Abstract

Summary

We recently demonstrated that patients with increased blood loss due to intraoperative coagulopathy show a persistent pre-, intra- and postoperative increase in fibrin monomer concentration. We thus tested the hypothesis that preoperative fibrin monomer concentrations can be used as a risk indicator for intraoperative blood loss in a study designed for diagnostic test evaluation in 168 patients admitted to the surgical service of our hospital. Intraoperative blood loss increased with preoperative fibrin monomer concentration (median blood loss of 50, 100, 200 and 400 ml in preoperative fibrin monomer quartile groups 1 to 4, p<0.001,ANOVA on ranks; interquartile comparisons p < 0.05 (4/6), MannWhitney Rank Sum test). In contrast, intraoperative blood loss was unrelated to preoperative values of prothrombin time, activated partial thromboplastin time and platelet count. By multivariate (logistic regression) analysis, only fibrin monomer remained a significant predictor of intraoperative blood loss > 500 ml when age, gender, BMI, fibrin monomer and the different types of surgical procedures (tumor surgery, vascular surgery, cholecystectomy, gastric banding, varicous vein surgery and hernia repair) were included as independent variables. Most importantly, accuracy evaluation showed that preoperative fibrin monomer concentration < 3 μg/l excluded intraoperative blood loss > 500 ml with 92% sensitivity and 95% negative predictive value. These results support our hypothesis that preoperative fibrin monomer concentrations are related to intraoperative blood loss in elective surgery. Fibrin monomer should be further investigated for it’s potential to serve as a routine tool for preoperative risk stratification of intraoperative bleeding.

Keywords

Acquired coagulation disorders - clinical/epidemiological studies - fibrinogen/fibrin

Full Text

References

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