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Thromb Haemost 2005; 94(02): 278-285
DOI: 10.1160/TH05-05-0306
Theme Issue Article
Schattauer GmbH

Staphylococcus aureus interactions with the endothelium

The role of bacterial “Secretable Expanded Repertoire Adhesive Molecules” (SERAM) in disturbing host defense systems
Triantafyllos Chavakis
1   Experimental Immunology Branch, NCI, NIH, Bethesda, Maryland, USA
,
Klaus Wiechmann
2   Institute for Biochemistry, Justus-Liebig-University Giessen, Giessen, Germany
,
Klaus T. Preissner
2   Institute for Biochemistry, Justus-Liebig-University Giessen, Giessen, Germany
,
Mathias Herrmann
3   Institute of Medical Microbiology and Hygiene, University of Saarland Hospital, Homburg/Saar, Germany
› Author Affiliations
Further Information

Publication History

Received: 04 May 2005

Accepted after major revision: 24 June 2005

Publication Date:
05 December 2017 (online)

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Summary

The intravascular maof nifestation Staphylococcus aureus infection is often associated with a severe, and sometimes catastrophic disease. Many host factors contribute to endothelial tropism of S.aureus including subendothelial matrix proteins,endothelial cell receptors, and platelets that are engaged together with S. aureus cell wall adhesins such as the fibronectin binding proteins. Recently, the role of secreted staphylococcal factors that were initially identified by virtue of their binding function with host proteins and ligands, has been reappraised in this regard. Among these, bacterial proteins without significant homology among each other, coagulase (Coa), the extracellular fibrinogen binding protein (Efb), the extracellular matrix binding protein (Emp), or the extracellular adhesive protein (Eap), are the most prominent ones to be associated with endovascular disease. Newly discovered interactions with host components may account for profound effects on immunmodulation and wound healing which are summarized in this short review and which ascribe an important role of these molecules in acute and chronic endo- and extravascular staphylococcal disease. Further research in the complex functional role of these "secretable expanded repertoire adhesive molecules" (SERAM) may not only help to increase our understanding in the pathogenesis of S. aureus infection but can specify novel targets for preventive or therapeutic strategies.

Keywords

Staphylococcus aureus - endothelium - extracellular adhesive protein - endovascular infection
 

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