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Thromb Haemost 2006; 95(03): 483-489
DOI: 10.1160/TH05-06-0421
Platelets and Blood Cells
Schattauer GmbH

Autosomal dominant thrombocytopenias with reduced expression of glycoprotein Ia

Patrizia Noris
1   Department of Internal Medicine, University of Pavia – IRCCS Policlinico San Matteo, Pavia, Italy
,
Gianni F. Guidetti
2   Department of Biochemistry, University of Pavia, Italy
,
Valeria Conti
3   Telethon Institute of Genetics and Medicine (TIGEM), Naples, Italy
,
Iride F. Ceresa
1   Department of Internal Medicine, University of Pavia – IRCCS Policlinico San Matteo, Pavia, Italy
,
Michele Di Pumpo
1   Department of Internal Medicine, University of Pavia – IRCCS Policlinico San Matteo, Pavia, Italy
,
Alessandro Pecci
1   Department of Internal Medicine, University of Pavia – IRCCS Policlinico San Matteo, Pavia, Italy
,
Mauro Torti
2   Department of Biochemistry, University of Pavia, Italy
,
Anna Savoia
3   Telethon Institute of Genetics and Medicine (TIGEM), Naples, Italy
,
Carlo L. Balduini
1   Department of Internal Medicine, University of Pavia – IRCCS Policlinico San Matteo, Pavia, Italy
› Author AffiliationsFinancial support: This work was supported by grant GP0019Y01 from the Italian Telethon Foundation and by grant from the Ministry of Education, University and Research (MIUR).
Further Information

Publication History

Received 15 June 2005

Accepted after revision 03 January 2006

Publication Date:
29 November 2017 (online)

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Summary

We have recently studieda case series of 46 unrelated patients with inherited thrombocytopenias and identified 18 cases that did not fit any known platelet disorder. In two unrelated families, a mild thrombocytopenia with normal platelet size was transmitted in an autosomal dominant fashion. Bleeding time was prolonged in 5 investigated patients. In all of them, flow cytometry and SDS-PAGE of platelet glycoproteins (GP) showed a reduced content of GPIa, a subunit of the GPIa-IIa complex (also known as integrin α2β1) that is a major collagen receptor on platelets.All other membrane GPs were within the normal range. GPIa deficiency was associated with severely reduced in vitro platelet adhesion to molecules known to interact selectively with GPIa. In vitro platelet aggregation was normal in all subjects, except for a suboptimal platelet response to fibrillar collagen in two patients.A mild defect of α-granules was observed in all affected subjects. No mutation was identified in the genes encoding for GPIa or GPIIa. Since no other similar cases have been reported in the literature, we suggest that an autosomal dominant thrombocytopenia associated with GPIa deficiency and α-granule defect represents a new form of inherited thrombocytopenia.

Keywords

Inherited thrombocytopenia - glycoprotein Ia - integrin α2β1 - collagen receptor
 

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