Interleukin-10 promoter polymorphism and venous thrombosis

Eva Cochery-Nouvellon; Fabien Vitry; Pascale Cornillet-Lefebvre; Nathalie Hezard; Lucile Gillot; Philippe Nguyen

doi:10.1160/TH06-01-0027

Thrombosis and Haemostasis, Inhaltsverzeichnis

Thromb Haemost 2006; 96(01): 24-28
DOI: 10.1160/TH06-01-0027

Blood Coagulation, Fibrinolysis and Cellular Haemostasis

Schattauer GmbH

Interleukin-10 promoter polymorphism and venous thrombosis

A case-control study

Eva Cochery-Nouvellon

¹Laboratoire Central d’hématologie

³Unité UPRES EA3796 IFR53, Faculté de Médecine et de Pharmacie, Université de Reims Champagne-Ardenne, France

,

Fabien Vitry

²Unité d’aide méthodologique, CHU Robert Debré

,

Pascale Cornillet-Lefebvre

¹Laboratoire Central d’hématologie

³Unité UPRES EA3796 IFR53, Faculté de Médecine et de Pharmacie, Université de Reims Champagne-Ardenne, France

,

Nathalie Hezard

¹Laboratoire Central d’hématologie

,

Lucile Gillot

¹Laboratoire Central d’hématologie

,

Philippe Nguyen

¹Laboratoire Central d’hématologie

³Unité UPRES EA3796 IFR53, Faculté de Médecine et de Pharmacie, Université de Reims Champagne-Ardenne, France

› Institutsangaben

Abstract

Summary

The human interleukin-10 promoter gene is highly polymorphic. IL-10 polymorphisms have been associated with various autoimmune and lymphoproliferative disorders. Although IL-10 has been shown to modulate thrombin generation in several experimental models, it is not known whether IL-10 polymorphisms could be a risk factor for venous thrombosis. We therefore conducted a case-control study comparing 74 consecutive patients who experienced at least one episode of documented venous thromboembolic event and 100 healthy controls. All subjects were Caucasians. Five polymorphisms of the IL-10 promoter gene were studied: two highly polymorphic dinucleotide repeats, IL-10 R and IL-10G, and three single nucleotide polymorphisms at position −1082, −819 and −592. Factor VG1691C Leiden mutation was systematically determined. Multivariate logistic regression analysis showed that IL-10 G13 and G10 alleles are independent risk factors for venous thrombosis (Odds ratio:OR = 3.33, p = 0.003 and OR = 2.83, p = 0.03, respectively). Furthermore, IL-10 G10 allele is more frequent in recurrent disease.

Keywords

Deep vein thrombosis - interleukin-10 - factor V Leiden - hereditary thrombosis risk factor

Volltext

Referenzen

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