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Thromb Haemost 2006; 96(04): 540-542
DOI: 10.1160/TH06-03-0130
Letters to the Editor
Schattauer GmbH

C-reactive protein influences shear stress-dependent platelet adhesion in patients with familiar hypercholesterolemia and coronary artery disease undergoing LDL apheresis

Lukas E. Spieker
1   Cardiology University Hospital, Zürich, Switzerland
,
Andreas J. Flammer
1   Cardiology University Hospital, Zürich, Switzerland
,
Nadja Amacker
1   Cardiology University Hospital, Zürich, Switzerland
,
Isabella Sudano
1   Cardiology University Hospital, Zürich, Switzerland
,
Juan J. Badimon
1   Cardiology University Hospital, Zürich, Switzerland
2   Cardiovascular Biology Research Laboratory, Zena and Michael A. Wiener Cardiovascular Institute, Mount Sinai School of Medicine, New York, New York, USA
,
Frank Ruschitzka
1   Cardiology University Hospital, Zürich, Switzerland
,
Thomas F. Lüscher
1   Cardiology University Hospital, Zürich, Switzerland
,
Georg Noll
1   Cardiology University Hospital, Zürich, Switzerland
,
Roberto Corti
1   Cardiology University Hospital, Zürich, Switzerland
› Author AffiliationsFinancial support: Our research was partly supported by the Swiss National Science Foundation (grant 32000BO-105758 to F.R., grant Nr. 32000B0–100318 to G.N. and grant Nr. 32000BO-109905/1 to R.C.).
Further Information

Publication History

Received 02 March 2006

Accepted after resubmission 28 August 2006

Publication Date:
29 November 2017 (online)

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  • References

  • 1 Ridker PM, Rifai N, Pfeffer MA. et al. Inflammation, pravastatin, and the risk of coronary events after myocardial infarction in patients with average cholesterol levels. Cholesterol and Recurrent Events (CARE) Investigators. Circulation 1998; 98: 839-44.
    CrossrefPubMedGoogle Scholar
  • 2 Liuzzo G, Biasucci LM, Gallimore JR. et al. The prognostic value of C-reactive protein and serum amyloid a protein in severe unstable angina. N Engl J Med 1994; 331: 417-24.
    CrossrefPubMedGoogle Scholar
  • 3 Verma S, Yeh ET. C-reactive protein and atherothrombosis-beyond a biomarker: an actual partaker of lesion formation. Am J Physiol Regul Integr Comp Physiol 2003; 285: R1253-6.
    CrossrefPubMedGoogle Scholar
  • 4 Ruggeri ZM. Platelets in atherothrombosis. Nat Med 2002; 08: 1227-34.
    CrossrefPubMedGoogle Scholar
  • 5 Henn V, Slupsky JR, Grafe M. et al. CD40 ligand on activated platelets triggers an reaction of endothelial cells. Nature 1998; 391: 591-4.
    CrossrefPubMedGoogle Scholar
  • 6 Spieker LE, Ruschitzka F, Badimon JJ. et al. Shear stress-dependent platelet function after LDL cholesterol apheresis. Thromb Res 2004; 113: 395-8.
    CrossrefPubMedGoogle Scholar
  • 7 Varon D, Dardik R, Shenkman B. et al. A new method for quantitative analysis of whole blood platelet interaction with extracellular matrix under flow conditions. Thromb Res 1997; 85: 283-94.
    CrossrefPubMedGoogle Scholar
  • 8 Shenkman B, Savion N, Dardik R. et al. Testing of platelet deposition on polystyrene surface under flow conditions by the cone and plate(let) analyzer: role of platelet activation, fibrinogen and von Willebrand factor. Thromb Res 2000; 99: 353-61.
    CrossrefPubMedGoogle Scholar
  • 9 Israels SJ AK. IMmunocytochemical and electron microscope studies of platelets. In: Platelets: A Practical Approach. Oxford University Press Inc; NewYork: 1996
    Google Scholar
  • 10 Ikeda Y, Handa M, Kawano K. et al. The role of von Willebrand factor and fibrinogen in platelet aggregation under varying shear stress. J Clin Invest 1991; 87: 1234-40.
    CrossrefPubMedGoogle Scholar
  • 11 Khreiss T, Jozsef L, Potempa LA. et al. Conformational rearrangement in C-reactive protein is required for proinflammatory actions on human endothelial cells. Circulation 2004; 109: 2016-22.
    CrossrefPubMedGoogle Scholar