Any effect of CYP2C9 variants on warfarin clearance in Chinese patients?

Joyce H. S. You; Zhong Zuo; Cindy M. Y. Lo; Limin Zhou; Hillary H. W. Yiu; Carrie T. S. Chau; Kai Chow Choi; David K. M. Choi; Raymond S. M. Wong; Gregory Cheng

doi:10.1160/TH06-04-0195

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 2007; 97(05): 866-868
DOI: 10.1160/TH06-04-0195

Letters to the Editor

Schattauer GmbH

Any effect of CYP2C9 variants on warfarin clearance in Chinese patients?

Authors

Joyce H. S. You

¹School of Pharmacy, Faculty of Medicine, The Chinese University of Hong Kong
Zhong Zuo

¹School of Pharmacy, Faculty of Medicine, The Chinese University of Hong Kong
Cindy M. Y. Lo

¹School of Pharmacy, Faculty of Medicine, The Chinese University of Hong Kong
Limin Zhou

¹School of Pharmacy, Faculty of Medicine, The Chinese University of Hong Kong
Hillary H. W. Yiu

¹School of Pharmacy, Faculty of Medicine, The Chinese University of Hong Kong
Carrie T. S. Chau

¹School of Pharmacy, Faculty of Medicine, The Chinese University of Hong Kong
Kai Chow Choi

²Centre for Epidemiology and Biostatistics, The Chinese University of Hong Kong
David K. M. Choi

¹School of Pharmacy, Faculty of Medicine, The Chinese University of Hong Kong
Raymond S. M. Wong

³Division of Haematology, Department of Medicine & Therapeutics, Faculty of Medicine, The Chinese University of Hong Kong; Hong Kong
Gregory Cheng

³Division of Haematology, Department of Medicine & Therapeutics, Faculty of Medicine, The Chinese University of Hong Kong; Hong Kong

Abstract

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References

References
1 Zhao F, Loke C, Rankin SC. et al. Novel CYP2C9 genetic variants in Asian subjects and their influence on maintenance warfarin dose. Clin Pharmacol Ther 2004; 76: 210-219.
2 Yuan HY, Chen JJ, Lee MTM. et al. A novel functional VKORC1 promoter polymorphism is associated with inter-individual and inter-ethnic differences in warfarin sensitivity. Hum Mol Genet 2005; 14: 1745-1751.
3 Chern HD, Ueng TH, Fu YP. et al. CYP2C9 polymorphism and warfarin sensitivity in Taiwan Chinese. Clin Chim Acta 2006; 367: 108-113.
4 You JHS, Chan FWH, Wong RSM. et al. Is INR between 2.0 and 3.0 the optimal level for Chinese patients on warfarin therapy for moderate-intensity anticoagulation?. Br J Clin Pharmacol 2005; 59: 582-587.
5 Holford NHG. Clinical pharmacokinetics and pharmacodynamics of warfarin. Understanding the dose-effect relationship. Clin Pharmacokinet 1986; 11: 483-504.
6 Chan E, McLachlan A, O’Reilly R. et al. Stereochemical aspects of warfarin drug interactions. Use of a combined pharmacokinetic-pharmacodynamic model. Clin Pharmacol Ther 1994; 56: 286-294.
7 Haber LT, Maier A, Gentry PR. et al. Genetic polymorphisms in assessing interindividual variability in delivered dose. Reg Toxicol Pharmacol 2002; 35: 177-197.
8 Veenstra DL, You JHS, Rieder MJ. et al. Association of vitamin K epoxide reductase complex 1 (VKORC1) variants with warfarin dose in a Hong Kong Chinese patient population. Pharmacogenet Genomics 2005; 15: 687-691.
9 Naidong W, Ring PR, Midtlien C. et al. Development and validation of a sensitive and robust LC-tandem MS method for the analysis of warfarin enantiomers in human plasma. J Pharm Biomed Anal 2001; 25: 219-226.
10 Takahashi H, Kashima T, Nomizo Y. et al. Metabolism of warfarin enantiomers in Japanese patients with heart disease having different CYP2C9 and CYP2C19 genotypes. Clin Pharmacol Ther 1998; 63: 519-528.
11 Takahashi H, Wilkinson G, Caraco Y. et al. Population differences in S-warfarin metabolism between CYP2C9 genotype-matched Caucasian and Japanese patients. Clin Pharmacol Ther 2003; 73: 253-263.
12 Takahashi H, Ieiri I, Wilkinson GR. et al. 5’-Flanking region polymorphisms of CYP2C9 and their relationship to S-warfarin metabolism in white and Japanese patients. Blood 2004; 103: 3055-3057.
13 Takahashi H, Wilkinson GR, Nutescu EA. et al. Different contributions of polymorphism in VKORC1 and CYP2C9 to intra- and inter-population differences in maintenance dose of warfarin in Japanese, Caucasians and African-Americans. Pharmacogenet Genomics 2006; 16: 101-110.
14 Sconce EA, Khan TI, Wynne HA. et al. The impact of CYP2C9 and VKORC1 genetic polymorphism and patient characteristics upon warfarin dose requirement: proposal for a new dosing regimen. Blood 2005; 106: 2329-2333.
15 Kamali F, Khan TI, King BP. et al. Contribution of age, body size, and CYP2C9 genotype to anticoagulant response to warfarin. Clin Pharmacol Ther 2004; 75: 204-212.
16 Wynne H, Cope L, Kelly P. et al. The influence of age, liver size and enantiomer concentrations on warfarin requirements. Br J Pharmacol 1995; 40: 203-207.
17 Scordo MG, Pengo V, Spina E. et al. Influence of CYP2C9 and CYP2C19 genetic polymorphism on warfarin maintenance dose and metabolic clearance. Clin Pharmacol Ther 2002; 72: 702-710.