Characterization of an acquired factor VIII inhibitor and plasmapheresis therapy in a patient with bullous pemphigoid

Guang-Sen Zhang; Wen-Li Zuo; Chong-Wen Dai; Yun-Xiao Xu; Jian-Kai Shen; Yun-Ya Luo; Yan Yi

doi:10.1160/TH06-04-0206

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 2006; 96(05): 692-694
DOI: 10.1160/TH06-04-0206

Letters to the Editor

Schattauer GmbH

Characterization of an acquired factor VIII inhibitor and plasmapheresis therapy in a patient with bullous pemphigoid

Guang-Sen Zhang

¹Division of Hematology, Institute of Molecular Hematology, the Second Xiang-Ya Hospital, Central South University, Chang Sha, Hunan, P. R. China

,

Wen-Li Zuo

¹Division of Hematology, Institute of Molecular Hematology, the Second Xiang-Ya Hospital, Central South University, Chang Sha, Hunan, P. R. China

,

Chong-Wen Dai

¹Division of Hematology, Institute of Molecular Hematology, the Second Xiang-Ya Hospital, Central South University, Chang Sha, Hunan, P. R. China

,

Yun-Xiao Xu

¹Division of Hematology, Institute of Molecular Hematology, the Second Xiang-Ya Hospital, Central South University, Chang Sha, Hunan, P. R. China

,

Jian-Kai Shen

¹Division of Hematology, Institute of Molecular Hematology, the Second Xiang-Ya Hospital, Central South University, Chang Sha, Hunan, P. R. China

,

Yun-Ya Luo

¹Division of Hematology, Institute of Molecular Hematology, the Second Xiang-Ya Hospital, Central South University, Chang Sha, Hunan, P. R. China

,

Yan Yi

¹Division of Hematology, Institute of Molecular Hematology, the Second Xiang-Ya Hospital, Central South University, Chang Sha, Hunan, P. R. China

› Author Affiliations

Abstract

Full Text

References

References
1 Lightburn E, Morand JJ, Graffin B. et al. Pemphigoid and acquired hemophilia. Ann Dermatol Venereol 2001; 128: 1229-31.
2 Mac Zekc, Thoma-Uszynski S, Schuler G. et al. Simultaneous onset of pemphigoid and factor VIII antibody hemophilia. Hautarzt 2002; 53: 412-5.
3 Vissink A, van Coevorden AM, Spijkervet FK. et al. Spontaneous blood blister formation swelling of the oral mucosa. Ned Tijdschr Tandheelkd 2003; 110: 359-61.
4 Patel RS, Harman KE, Nichols C. et al. Bullous pemphigoid and acquired hemophilia. Postgrad Med J 2006; 82: 3.
5 Kasper CK, Aledort LM, Counts RB. et al. A more uniform measurement of factor VIII inhibitors. Thromb Diath Haemorr 1975; 34: 869-72.
6 Fulcher CA, de Graaf Mahoney S, Roberts JR. et al. Localization of human factor VIII inhibitor epitopes to two polypeptide fragments. Proc Natl Acad Sci USA 1985; 82: 7728.
7 Spiegel Jr. PC, Stoddard BL. Optimization of factor VIII replacement therapy: can structural studies help in evading antibody inhibitors?. Brit J Haemotol 2002; 119: 310-22.
8 Lavigne-Lissalde G, Schved JF, Granier C. et al. Anti-factor VIII antibodies, a 2005 update. Thromb Haemost 2005; 94: 760-9.
9 Fay PS, Scandella D. Human inhibitor antibodies specific for the factor VIII A2 domain disrupt the interaction between the subunit and factor IXa. J Biol Chem 1999; 274: 29826-30.
10 Scandella D, DeGraaf Mahoney S, Mattingly M. et al. Epitope mapping of human factor VIII inhibitor antibodies by deletion analysis of factor VIII fragments expressed in Eschericha coli . Proc Natl Acad Sci USA 1988; 85: 6152-6.
11 Lollar P, Parker WT, Fay PJ. Coagulant properties of hybrid human/porcine factor VIII molecules. J Biol Chem 1992; 267: 2362-7.
12 Huang CC, Shen MC, Chen JY. et al. Epitope mapping of factor VIII inhibitor antibodies of Chinese origin. Brit J Haemotol 2001; 113: 915-24.