Thromb Haemost 2006; 96(05): 578-583
DOI: 10.1160/TH06-05-0285
Theme Issue Article
Schattauer GmbH

Evaluation of ProC Global assay in women with a history of venous thromboembolism on hormonal therapy

Galit Sarig
1   Thrombosis and Hemostasis Unit
4   Technion-Israel Institute of Technology, Haifa, Israel
,
Irit Aberbach
1   Thrombosis and Hemostasis Unit
4   Technion-Israel Institute of Technology, Haifa, Israel
,
Liliana Schliamser
3   Hematology Department, Bnai Zion Medical Center and the Bruce Rappaport Faculty of Medicine
,
Zeev Blumenfeld
2   Department of Obstetrics and Gynecology, Rambam Health Care Campus
4   Technion-Israel Institute of Technology, Haifa, Israel
,
Benjamin Brenner
1   Thrombosis and Hemostasis Unit
4   Technion-Israel Institute of Technology, Haifa, Israel
› Institutsangaben
Weitere Informationen

Publikationsverlauf

Received 13. Mai 2006

Accepted after resubmission 12. Oktober 2006

Publikationsdatum:
01. Dezember 2017 (online)

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Summary

The risk of thrombosis in women increases significantly during treatment with hormonal therapy (HT). The aim of this study was to evaluate ProC Global assay in women with a history of venous thromboembolism (VTE) while using HT. Protein C activation time normalized ratio (PCAT-NR) levels were significantly lower in 32 women with a history ofVTE while using HT (0.72 ± 0.1) compared with 56 healthy controls without HT, matched by age at blood sampling (0.99 ± 0.2) and 40 healthy controls with HT, matched by age and HT at VTE event (0.94 ± 0.2) (P<0.001 for both). PCAT-NR lower than the cut-off level of 0.8 was found in 23/32 (72%) patients compared with 5/56 (9%) age-matched controls (OR=26, 95%CI: 7-106, P<0.001) and 9/40 (22.5%) of HT-matched controls (OR=9, 95%CI: 2.7-30, P<0.001). Any thrombophilic risk factor was found in 20/32 (62.5%) of patients compared with 12/56 (21.4%) of agematched controls (OR=6, 95%CI: 2.1-10, P<0.001) and 12/40 (30%) of HT-matched controls (OR=4, 95%CI: 1.3-11.8, P=0.006).Out of the variables that are risk factors of VTE as age, HT or thrombophilic risk factor, ProC Global assay was found in the multivariate analysis - logistic regression, as the parameter that was the most associated with patient group [Exp(B)=15.8, 95% CI: 4.2-59.0, P<0.001]. In conclusion, abnormal PCAT-NR is associated with VTE in women using HT. ProC Global assay may potentially serve asa diagnostic tool for evaluating the risk of VTE in women prior to administration of HT.