The efficacy of rituximab in the treatment of inhibitor-associated hemostatic disorders

Massimo Franchini; Dino Veneri; Giuseppe Lippi; Rachel Stenner

doi:10.1160/TH06-06-0317

Thrombosis and Haemostasis, Inhaltsverzeichnis

Thromb Haemost 2006; 96(02): 119-125
DOI: 10.1160/TH06-06-0317

Review Article

Schattauer GmbH

The efficacy of rituximab in the treatment of inhibitor-associated hemostatic disorders

Massimo Franchini

¹Servizio di Immunoematologia e Trasfusione– Centro Emofilia, Azienda Ospedaliera di Verona, Verona

,

Dino Veneri

²Dipartimento di Medicina Clinica e Sperimentale, Sezione di Ematologia, Università di Verona, Verona, Italy

,

Giuseppe Lippi

³Istituto di Chimica e Microscopia Clinica, Dipartimento di Scienze Biomediche e Morfologiche, Università di Verona

,

Rachel Stenner

⁴New Hall, University of Cambridge, Cambridge, UK

› Institutsangaben

Abstract

Summary

Rituximab is a chimeric anti-CD20 monoclonal antibody active against normal and malignant B cells which has proven to be effective in the therapy of CD-20 positive lymphomas. Its B-cell cytotoxic action has also been exploited in many non-malignant autoimmune disorders in which it has been used with the aim of interfering with the production of pathologic antibodies. The present knowledge regarding the use of rituximab in antibodyassociated disorders of hemostasis (i.e. idiopathic thrombocytopenic purpura, thrombotic thrombocytopenic purpura, acquired hemophilia A, congenital hemophilia with inhibitors, acquired inhibitors against coagulation factors) is presented briefly in this review. The results suggest that rituximab can be useful in the treatment of disorders of hemostasis associated with inhibitor formation. Although collectively the number of patients treated is now quite substantial, most of the data are drawn from isolated case reports or descriptions of small, uncontrolled series. Large, prospective, randomized trials are, therefore, needed to confirm the positive, preliminary results.

Keywords

Rituximab - inhibitor - coagulation disorders

Volltext

Referenzen

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