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Thromb Haemost 2007; 97(03): 343-347
DOI: 10.1160/TH06-09-0488
Theme Issue Article
Schattauer GmbH

Protein C inhibitor, a serpin with functions in- and outside vascular biology

Margarethe Geiger
1   Department of Vascular Biology and Thrombosis Research, Center for Biomolecular Medicine and Pharmacology, Medical University of Vienna, Vienna, Austria
› Institutsangaben
Weitere Informationen

Publikationsverlauf

Received 01. September 2006

Accepted 14. Februar 2006

Publikationsdatum:
28. November 2017 (online)

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Summary

Human protein C inhibitor (PCI), a serpin-type protease inhibitor originally described as an inhibitor of activated protein C, has broad protease reactivity. In addition to its activities within the blood clotting and fibrinolytic cascades, it seems to participate in several biological processes including reproductiorn and tumor growth. This review summarizes the current understanding of PCI function, regulation, and potential biological role.

Keywords

Serpins - phospholipids - proteases
 

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