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Thromb Haemost 2007; 97(04): 635-641
DOI: 10.1160/TH06-09-0517
Cardiovascular Biology and Cell Signalling
Schattauer GmbH

Factor XIII Val34Leu variant and the risk of myocardial infarction

A meta-analysis
Mona Shafey
1   Department of Medicine, University of Ottawa, Ontario, Canada
,
Josdalyne L. Anderson
2   Ottawa Health Research Institute, Ontario, Canada
,
Dimitri Scarvelis
1   Department of Medicine, University of Ottawa, Ontario, Canada
,
Steven P. Doucette
2   Ottawa Health Research Institute, Ontario, Canada
,
France Gagnon
4   Department of Public Health Sciences, University of Toronto, Ontario, Canada
,
Philip S. Wells   *
1   Department of Medicine, University of Ottawa, Ontario, Canada
2   Ottawa Health Research Institute, Ontario, Canada
3   Department of Epidemiology and Community Medicine, University of Ottawa, Ontario, Canada
› Author AffiliationsFinancial support: Heart and Stroke foundation of Ontario Program Grant no. PRG 5513
Further Information

Publication History

Received 13 September 2006

Accepted after resubmission 01 February 2007

Publication Date:
24 November 2017 (online)

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Summary

Genetic factors are thought to contribute to the pathogenesis of acute myocardial infarction (AMI).A common variant of factor XIII (FXIII), FXIII Val34Leu, may be protective against developing an AMI, but various studies show conflicting results. We performed a meta-analysis to determine whether the FXIII Val34Leu variant is associated with a decreased risk of AMI. One hundred ninety-five articles were reviewed and 12 case-control studies were selected. We included studies involving patients with objectively diagnosed AMIs (WHO criteria), provided that FXIII Val34Leu genotyping data were available. Inclusion decisions, quality assessment, and data extraction were conducted by two reviewers. Hypothesizing that the Leu allele was protective, we performed three analyses with the Val/Val genotype as the reference group. Pooled odds ratios (OR) and their 95% confidence intervals (95% CI) were determined. Prior to pooling, heterogeneity testing was performed using the I 2 statistic. These studies included a total of 8,743 patients, of which 3,663 were AMI patients and 5,080 were healthy controls. Using the random effects methods, protective effects were seen with the Leu/Val genotype alone (OR 0.79, 95% CI 0.68–0.93) and with Leu/Val and Leu/Leu genotypes combined (OR 0.79, 95% CI 0.66–0.93).There was also a protective effect with the Leu/Leu genotype alone, (not statistically significant: OR 0.83, 95% CI 0.61–1.12), likely due to the low frequency of this genotype. These results suggest that there is an association between the factor XIII Leu allele and a modest protective effect against AMI and may provide useful information in profiling susceptibility to myocardial infarction.

Keywords

Factor XIII - genetic - meta-analysis - myocardial infarction - risk factor

* Dr. Wells is the recipient of a Canada Research Chair Award.


 

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