Persistence of phosphatidylserine exposure on activated platelets in vivoin rabbits

Margaret L. Rand; Hong Wang; Annie K. W. Bang; Marian A. Packham; John Freedman

doi:10.1160/TH06-12-0702

Thrombosis and Haemostasis, Inhaltsverzeichnis

Thromb Haemost 2007; 98(02): 477-478
DOI: 10.1160/TH06-12-0702

Letters to the Editor

Schattauer GmbH

Persistence of phosphatidylserine exposure on activated platelets in vivoin rabbits

Margaret L. Rand

¹Division of Haematology/Oncology and Program in Physiology and Experimental Medicine, The Hospital for Sick Children

²Department of Laboratory Medicine and Pathobiology

³Department of Biochemistry, University of Toronto

,

Hong Wang

¹Division of Haematology/Oncology and Program in Physiology and Experimental Medicine, The Hospital for Sick Children

,

Annie K. W. Bang

⁴Division of Transfusion Medicine, St. Michael’s Hospital

,

Marian A. Packham

³Department of Biochemistry, University of Toronto

,

John Freedman

⁵Department of Medicine, University of Toronto; Toronto, Canada

⁴Division of Transfusion Medicine, St. Michael’s Hospital

⁵Department of Medicine, University of Toronto; Toronto, Canada

References
1 Zwaal RF, Schroit AJ. Pathophysiologic implications of membrane phospholipid asymmetry in blood cells. Blood 1997; 89: 1121-1132.
2 Heemskerk JW, Bevers EM, Lindhout T. Platelet activation and blood coagulation. Thromb Haemost 2002; 88: 186-193.
3 Leung R, Gwozdz AM, Wang H. et al. Persistence of procoagulant surface expression on activated human platelets: involvement of apoptosis and aminophospholipid translocase activity. J Thromb Haemost 2007; 5: 560-570.
4 Rand ML, Wang H, Bang KW. et al. Procoagulant surface exposure and apoptosis in rabbit platelets: association with shortened survival and steady-state senescence. J Thromb Haemost 2004; 2: 651-659.
5 Berger G, Hartwell DW, Wagner DD. Platelet death. An apoptotic-like process? Blood 1998; 92: 347a.
6 Martin SJ, Reutelingsperger CP, McGahon AJ. et al. Early redistribution of plasma membrane phosphatidylserine is a general feature of apoptosis regardless of the initiating stimulus: inhibition by overexpression of Bcl-2 and Abl. J Exp Med 1995; 182: 1545-1556.
7 Kuypers FA, de Jong K. The role of phosphatidylserine in recognition and removal of erythrocytes. Cell Mol Biol 2004; 50: 147-158.
8 Castedo M, Hirsch T, Susin SA. et al. Sequential acquisition of mitochondrial and plasma membrane alterations during early lymphocyte apoptosis. J Immunol 1996; 157: 512-521.
9 Rand ML, Wang H, Bang KW. et al. Rapid clearance of procoagulant platelet-derived microparticles from the circulation of rabbits. J Thromb Haemost 2006; 4: 1621-1623.
10 Kinlough-Rathbone RL, Perry DW. Prolonged expression of procoagulant activity of human platelets degranulated by thrombin. Thromb Haemost 1995; 74: 958-961.