Cardiovascular risk factors and global risk of fatal cardiovascular disease are positively correlated between partners of 802 married couples from different European countries

Augusto Di Castelnuovo; Gianni Quacquaruccio; Arnout Jozef; Francesco Paolo Cappuccio; Michel de Lorgeril; Carla Dirckx; Maria Benedetta Donati; Vittorio Krogh; Alfonso Siani; Marten C. J. M. van Dongen; Francesco Zito; Giovanni de Gaetano; Licia Iacoviello; European Collaborative Group of the IMMIDIET Project; on behalf of

doi:10.1160/TH07-01-0024

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 2007; 98(03): 648-655
DOI: 10.1160/TH07-01-0024

Cardiovascular Biology and Cell Signalling

Schattauer GmbH

Cardiovascular risk factors and global risk of fatal cardiovascular disease are positively correlated between partners of 802 married couples from different European countries

Report from the IMMIDIET project

Augusto Di Castelnuovo

¹Research Laboratories, “John Paul II” Centre for High Technology Research and Education in Biomedical Sciences, Catholic University, Campobasso, Italy

,

Gianni Quacquaruccio

¹Research Laboratories, “John Paul II” Centre for High Technology Research and Education in Biomedical Sciences, Catholic University, Campobasso, Italy

,

Arnout Jozef

²Centre for Molecular and Vascular Biology, Katholieke Universiteit Leuven, Leuven, Belgium

,

Francesco Paolo Cappuccio

³Clinical Sciences Research Institute, Warwick Medical School, Coventry, United Kingdom

,

Michel de Lorgeril

⁴Nutrition, Vieillissement et Maladies Cardiovasculaires (NVMCV), UFR de Médecine, Domaine de la Merci, La Tronche, France

,

Carla Dirckx

²Centre for Molecular and Vascular Biology, Katholieke Universiteit Leuven, Leuven, Belgium

,

Maria Benedetta Donati

¹Research Laboratories, “John Paul II” Centre for High Technology Research and Education in Biomedical Sciences, Catholic University, Campobasso, Italy

,

Vittorio Krogh

⁵Nutritional Epidemiology Unit, National Cancer Institute, Milan, Italy

,

Alfonso Siani

⁶Unit of Epidemiology & Population Genetics, Institute of Food Sciences, CNR, Avellino, Italy

,

Marten C. J. M. van Dongen

⁷Department of Epidemiology, Maastricht University, Maastricht, The Netherlands

,

Francesco Zito

¹Research Laboratories, “John Paul II” Centre for High Technology Research and Education in Biomedical Sciences, Catholic University, Campobasso, Italy

,

Giovanni de Gaetano

¹Research Laboratories, “John Paul II” Centre for High Technology Research and Education in Biomedical Sciences, Catholic University, Campobasso, Italy

,

Licia Iacoviello

¹Research Laboratories, “John Paul II” Centre for High Technology Research and Education in Biomedical Sciences, Catholic University, Campobasso, Italy

,

European Collaborative Group of the IMMIDIET Project

› Author Affiliations

Abstract

Summary

Shared environmental factors may confer to spouses a similar risk for cardiovascular disease. We aimed at investigating in pairs the concordance in risk factors for cardiovascular disease and in global risk of cardiovascular events. In the framework of the IMMIDIET Project, married couples, recruited randomly from general practice, were studied. One thousand six hundred and four apparently healthy subjects aged 25–74 years from three different European populations were enrolled. Individual cardiovascular risks were estimated using SCORE risk equations. Age was strongly correlated within couples (r=0.86, P<0.0001). In multivariate model, within-pair correlation was high for social status (r=049; percentage of explained variation=24%) and percent of calories from lipids (r=0.34; 12%). Concerning conventional metabolic risk factors, percentage of explained variation varied from 0.5% (triglycerides) to 11% (glucose). Among new risk factors, activated factor VII showed the strongest correlation (r=0.28) and C-reactive protein the lowest (r=0.13). Either total, coronary or non-coronary risk estimates at 10 years were strongly correlated within pairs: the risk of a member explained about two thirds of the cardiovascular risk of the partner. Spouse pairs share common lifestyle habits, common and new metabolic risk factors and the predicted global risk of cardiovascular events. If the individual risk of a person is influenced by the risk of his/her partner, decreasing the risk in a member of the pair should also decrease the risk in the partner. These concepts may have important public health consequences in targeting screening or disease prevention measures towards partners of people with cardiovascular risk.

Keywords

Epidemiology - prevention - risk factors - cardiovascular disease

Full Text

References

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