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Thromb Haemost 2007; 98(03): 621-626
DOI: 10.1160/TH07-02-0095
Blood Coagulation, Fibrinolysis and Cellular Haemostasis
Schattauer GmbH

Influence of lipids and obesity on haemorheological parameters in patients with deep vein thrombosis

Amparo Vayá
1   Haemorheology and Thrombosis Unit, Department of Clinical Pathology, La Fe University Hospital, Valencia, Spain
,
Cristina Falcó
1   Haemorheology and Thrombosis Unit, Department of Clinical Pathology, La Fe University Hospital, Valencia, Spain
,
María Simó
1   Haemorheology and Thrombosis Unit, Department of Clinical Pathology, La Fe University Hospital, Valencia, Spain
,
Fernando Ferrando
1   Haemorheology and Thrombosis Unit, Department of Clinical Pathology, La Fe University Hospital, Valencia, Spain
,
Yolanda Mira
1   Haemorheology and Thrombosis Unit, Department of Clinical Pathology, La Fe University Hospital, Valencia, Spain
,
José Todolí
2   Internal Medicine Service, La Fe University Hospital, Valencia, Spain
,
Francisco España
3   Research Centre, La Fe University Hospital, Valencia, Spain
,
Dolores Corella
4   Genetic and Molecular Epidemiology Unit, School of Medicine, University of Valencia, Spain
5   CIBER Fisiopatología de la obesidad y nutrición, Instituto de Salud Carlos III, Madrid, Spain
› Author Affiliations Financial support: This study was partially supported by grants from Instituto de Salud Carlos III (CIBER CB06/03/0035 and Red RECAVA RD06/0014/0004), Spain.
Further Information

Publication History

Received 07 February 2007

Accepted after resubmission 29 May 2007

Publication Date:
28 November 2017 (online)

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Summary

It is not well established whether haemorheological alterations constitute independent risk factors for deep vein thrombosis (DVT).We have determined in 149 DVT patients and in 185 control subjects the body mass index (BMI), the haemorheological profile: blood viscosity (BV), plasma viscosity (PV), fibrinogen (Fg), erythrocyte aggregation (EA), erythrocyte deformability (ED) and plasma lipids. In the crude analysis BMI, Fg, PV, EA, triglycerides (TG) and ApoB were statistically higher and HDL cholesterol (HDL-Chol) statistically lower in DVT patients than in controls. No differences in BV and ED were observed. After BMI adjustment, Fg, PV and EA remained statistically higher in DVT cases than in controls (P=0.013; P=0.012; P=0.013; P=0.028, respectively). When the risk of DVT associated with these variables (using cut-offs that corresponded to the mean plus one SD of the control group) was estimated, EA>8.2 and PV>1.28 mPa·s were significantly associated with DVT even further adjustment for lipids and obesity (OR=2.78, P=0.004; OR=1.91, P=0.024, respectively). However, PV did not remain statistically significant after additional adjustment for Fg. When we consider together all the analyzed variables in order to control every variable for each other, TG>175 mg/dl (OR=3,2,P=0.004) and BMI>30 kg/m2 (OR=3.5, P=0.003), were also independently associated with a greater risk of DVT. Our results suggest that increased EA constitute an independent risk factor for DVT. However, when associated to hyperlipidaemia and obesity it further increases thrombotic risk.

Keywords

Deep vein thrombosis - lipids - obesity - haemorheology
 

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