Influence of lipids and obesity on haemorheological parameters in patients with deep vein thrombosis

Amparo Vayá; Cristina Falcó; María Simó; Fernando Ferrando; Yolanda Mira; José Todolí; Francisco España; Dolores Corella

doi:10.1160/TH07-02-0095

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 2007; 98(03): 621-626
DOI: 10.1160/TH07-02-0095

Blood Coagulation, Fibrinolysis and Cellular Haemostasis

Schattauer GmbH

Influence of lipids and obesity on haemorheological parameters in patients with deep vein thrombosis

Authors

Amparo Vayá

¹Haemorheology and Thrombosis Unit, Department of Clinical Pathology, La Fe University Hospital, Valencia, Spain
Cristina Falcó

¹Haemorheology and Thrombosis Unit, Department of Clinical Pathology, La Fe University Hospital, Valencia, Spain
María Simó

¹Haemorheology and Thrombosis Unit, Department of Clinical Pathology, La Fe University Hospital, Valencia, Spain
Fernando Ferrando

¹Haemorheology and Thrombosis Unit, Department of Clinical Pathology, La Fe University Hospital, Valencia, Spain
Yolanda Mira

¹Haemorheology and Thrombosis Unit, Department of Clinical Pathology, La Fe University Hospital, Valencia, Spain
José Todolí

²Internal Medicine Service, La Fe University Hospital, Valencia, Spain
Francisco España

³Research Centre, La Fe University Hospital, Valencia, Spain
Dolores Corella

⁴Genetic and Molecular Epidemiology Unit, School of Medicine, University of Valencia, Spain

⁵CIBER Fisiopatología de la obesidad y nutrición, Instituto de Salud Carlos III, Madrid, Spain

Abstract

Summary

It is not well established whether haemorheological alterations constitute independent risk factors for deep vein thrombosis (DVT).We have determined in 149 DVT patients and in 185 control subjects the body mass index (BMI), the haemorheological profile: blood viscosity (BV), plasma viscosity (PV), fibrinogen (Fg), erythrocyte aggregation (EA), erythrocyte deformability (ED) and plasma lipids. In the crude analysis BMI, Fg, PV, EA, triglycerides (TG) and ApoB were statistically higher and HDL cholesterol (HDL-Chol) statistically lower in DVT patients than in controls. No differences in BV and ED were observed. After BMI adjustment, Fg, PV and EA remained statistically higher in DVT cases than in controls (P=0.013; P=0.012; P=0.013; P=0.028, respectively). When the risk of DVT associated with these variables (using cut-offs that corresponded to the mean plus one SD of the control group) was estimated, EA>8.2 and PV>1.28 mPa·s were significantly associated with DVT even further adjustment for lipids and obesity (OR=2.78, P=0.004; OR=1.91, P=0.024, respectively). However, PV did not remain statistically significant after additional adjustment for Fg. When we consider together all the analyzed variables in order to control every variable for each other, TG>175 mg/dl (OR=3,2,P=0.004) and BMI>30 kg/m² (OR=3.5, P=0.003), were also independently associated with a greater risk of DVT. Our results suggest that increased EA constitute an independent risk factor for DVT. However, when associated to hyperlipidaemia and obesity it further increases thrombotic risk.

Keywords

Deep vein thrombosis - lipids - obesity - haemorheology

Full Text

References

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