Chemokines at large: In-vivo mechanisms of their transport, presentation and clearance

Ian G. Colditz; Martin A. Schneider; Monika Pruenster; Antal Rot

doi:10.1160/TH07-02-0105

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 2007; 97(05): 688-693
DOI: 10.1160/TH07-02-0105

Theme Issue Article

Schattauer GmbH

Chemokines at large: In-vivo mechanisms of their transport, presentation and clearance

Ian G. Colditz

¹CSIRO Livestock Industries, Armidale, New South Wales, Australia

,

Martin A. Schneider

²Novartis Institutes of Biomedical Research, Vienna, Austria

,

Monika Pruenster

²Novartis Institutes of Biomedical Research, Vienna, Austria

,

Antal Rot

²Novartis Institutes of Biomedical Research, Vienna, Austria

› Author Affiliations

Abstract

Summary

Compelling evidence implicates chemokines in the induction of leukocyte emigration from blood into tissues.This arguably most fundamental effect of chemokines is accomplished by triggering cognate classical G-protein-coupled chemokine receptors on the leukocyte surface. In vitro, these same receptors mediate leukocyte migration; however, the mechanisms of chemokine-induced migration differ between in-vivo and in-vitro settings. Leukocyte egress from blood is greatly influenced by haemodynamic conditions and requires full cooperation of endothelial cells.The behaviour of chemokines in their“native habitat” in vivo is controlled by their interaction with several accessory molecules which influence immobilisation, transport, clearance and degradation of chemokines and thereby determine the sites and duration of their action. Here we discuss peculiarities of the invivo actions of chemokines,the mechanisms of chemokine interaction with receptors and auxiliary molecules including interceptors, glycosaminoglycans and enzymes and illustrate how these interactions influence the outcome of chemokine activities in vivo.

Keywords

Receptor - interceptor - decoy - leukocyte - emigration

Full Text

References

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