Invasion mechanisms of Gram-positive pathogenic cocci

Patric D. Nitsche-Schmitz; Manfred Rohde; Gursharan S. Chhatwal

doi:10.1160/TH07-03-0179

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 2007; 98(03): 488-496
DOI: 10.1160/TH07-03-0179

Theme Issue Article

Schattauer GmbH

Invasion mechanisms of Gram-positive pathogenic cocci

Patric D. Nitsche-Schmitz

¹Helmholtz Centre for Infection Research (HZI), Microbial Pathogenesis, Braunschweig, Germany

,

Manfred Rohde

¹Helmholtz Centre for Infection Research (HZI), Microbial Pathogenesis, Braunschweig, Germany

,

Gursharan S. Chhatwal

¹Helmholtz Centre for Infection Research (HZI), Microbial Pathogenesis, Braunschweig, Germany

› Author Affiliations

Abstract

Summary

Gram-positive cocci are important human pathogens. Streptococci and staphylococci in particular are a major threat to human health,since they cause a variety of serious invasive infections. Their invasion into normally sterile sites of the host depends on elaborated bacterial mechanisms that involve adhesion to the host tissue, its degradation, internalisation by host cells, and passage through epithelia and endothelia. Interactions of bacterial surface proteins with proteins of the host’s extracellular matrix as well as with cell surface receptors are crucial factors in these processes, and some of the key mechanisms are similar in many pathogenic Gram-positive cocci.Therapies that interfere with these mechanisms may become efficient alternatives to today’s antibiotic treatments.

Keywords

Streptococcus - Staphylococcus - pathogenesis - invasion - internalisation

Full Text

References

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