Differences in functional roles between activated platelets and platelet-derived microparticles

• References

• 1 Sinauridze EI, Kireev DA, Popenko NY. et al. Platelet microparticle membranes have 50- to 100-fold higher specific procoagulant activity than activated platelets. Thromb Haemost 2007; 97: 425-434.
• 2 Reininger AJ, Heijnen HFG, Schumann H. et al. Mechanism of platelet adhesion to von Willebrand factor and microparticle formation under high shear stress. Blood 2006; 107: 3537-3545.
• 3 Miyazaki Y, Nomura S, Miyake T. et al. High shear stress can initiate both platelet aggregation and shedding of procoagulant containing microparticles. Blood 1996; 88: 3456-3464.
• 4 Pontiggia L, Steiner B, Ulrichts H. et al. Platelet microparticle formation and thrombin generation under high shear are effectively suppressed by a monoclonal antibody against GPIba. Thromb Haemost 2006; 96: 774-780.
• 5 Pereira J, Alfaro G, Manuela G. et al. Circulating platelet-derived microparticles in systemic lupus erythematosus. Association with increased thrombin generation and procoagulant state. Thromb Haemost 2006; 95: 94-99.
• 6 Nomura S, Tandon NN, Nakamura T. et al. Highshear- stress-induced activation of platelets and microparticles enhances expression of cell adhesion molecules in THP-1 and endothelial cells. Atherosclerosis 2001; 158: 277-287.
• 7 Tan KT, Lip GYH. The potential role of platelet microparticles in atherosclerosis. Thromb Haemost 2005; 94: 488-492.
• 8 Rectenwald JE, Myers DD, Hawley AE. et al. D-dimer, P-selectin, and microparticles: novel markers to predict deep venous thrombosis a pilot study. Thromb Haemost 2005; 94: 1312-1317.
• 9 Matsumoto N, Nomura S, Kamihata H. et al. Increased level of oxidized LDL-dependent monocytederived microparticles in acute coronary syndrome. Thromb Haemost 2004; 91: 146-154.
• 10 Hron G, Kollars M, Weber H. et al. Tissue factorpositive microparticles: cellular origin and association with coagulation activation in patients with colorectal cancer. Thromb Haemost 2007; 97: 119-123.
• 11 Poitevin S, Cochery-Nouvellon E, Dupont A. et al. Monocyte IL-10 produced in response to lipopolysaccharide modulates thrombin generation by inhibiting tissue factor expression and release of active tissue factor- bound microparticles. Thromb Haemost 2007; 97: 598-607.
• 12 Smalley DM, Root KE, Cho HJ. et al. Proteomic discovery of 21 proteins espressed in human plasmaderived but not platelet-derived microparticles. Thromb Haemost 2007; 97: 67-80.