Thrombophilia in young patients with cryptogenic stroke and patent foramen ovale (PFO)

Pietro Offelli; Mario Zanchetta; Luigi Pedon; Filippo Marzot; Umberto Cucchini; Cinzia Pegoraro; Sabino Iliceto; Vittorio Pengo

doi:10.1160/TH07-04-0243

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 2007; 98(04): 906-907
DOI: 10.1160/TH07-04-0243

Case Report

Schattauer GmbH

Thrombophilia in young patients with cryptogenic stroke and patent foramen ovale (PFO)

Pietro Offelli

¹Clinical Cardiology, Thrombosis Centre, University Hospital, Padova, Italy

,

Mario Zanchetta

²Division of Cardiology, District Hospital, Cittadella, Italy

,

Luigi Pedon

²Division of Cardiology, District Hospital, Cittadella, Italy

,

Filippo Marzot

¹Clinical Cardiology, Thrombosis Centre, University Hospital, Padova, Italy

,

Umberto Cucchini

¹Clinical Cardiology, Thrombosis Centre, University Hospital, Padova, Italy

,

Cinzia Pegoraro

¹Clinical Cardiology, Thrombosis Centre, University Hospital, Padova, Italy

,

Sabino Iliceto

¹Clinical Cardiology, Thrombosis Centre, University Hospital, Padova, Italy

,

Vittorio Pengo

¹Clinical Cardiology, Thrombosis Centre, University Hospital, Padova, Italy

› Author Affiliations

Abstract

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References

References
1 Leys D, Bandu L, Henon H. et al. Clinical outcome in 287 consecutive young adults (15 to 45 years) with ischemic stroke.. Neurology 2002; 59: 26-33.
2 Overell JR, Bone I, Less KR. Interatrial septal abnormalities and stroke: a meta-analysis of case-control studies.. Neurology 2000; 55: 1172-1179.
3 Kizer JR, Devereux RB. Patent Foramen Ovale in Young Adults with Unexplained Stroke. N Engl J Med 2005; 353: 2361-2372.
4 Stollberger C, Slany J, Schuster I. et al. The prevalence of deep venous thrombosis in patients with suspected paradoxical embolism.. Ann Intern Med 1994; 120: 347-351.
5 Falk RH. PFO or UFO? The role of a patent foramen ovale in cryptogenic stroke.. Am Heart J 1991; 121: 1264-1266.
6 Lethen H, Flachskampf F, Schneider R. et al. Frequency of deep vein thrombosis in patients with patent foramen ovale and ischemic stroke or transient ischemic attack.. Am J Cardiol 1997; 80: 1066-1069.
7 Cramer S, Rordorf G, Maki J. et al. Increased pelvic vein thrombi in cryptogenic stroke: Results of the paradoxical emboli from large veins in ischemic stroke (PELVIS) study.. Stroke 2004; 35: 46-50.
8 Adams Jr HP, Bendixen BH, Kappelle LJ. et al. Classification of subtype of acute ischemic stroke. Definitions for use in a multicenter clinical trial. TOAST. Trial of Org 10172 in Acute Stroke Treatment.. Stroke 1993; 24: 35-41.
9 Bertina RM, Koeleman BP, Koster T. et al. Mutation in blood coagulation factor V associated with resistance to activated protein C.. Nature 1994; 369: 64-67.
10 Poort SR, Rosendaal FR, Reitsma PH. et al. A common genetic variation in the 3’-untranslated region of the prothrombin gene is associated with elevated plasma prothrombin levels and an increase in venous thrombosis.. Blood 1996; 88: 3698-3703.
11 Pengo V, Biasiolo A, Gresele P. et al. on behalf of Participating Centres of Italian Federation of Thrombosis Centres (FCSA). Survey of lupus anticoagulant diagnosis by central evaluation of positive plasma samples.. J Thromb Haemost 2007; 5: 925-930.
12 Pengo V, Biasiolo A, Fior MG. Autoimmune antiphospholipid antibodies are directed against a cryptic epitope expressed when b2-glycoprotein-I is bound to a suitable surface.. Thromb Haemost 1995; 73: 29-34.
13 Miyakis S, Lockshin MD, Atsumi T. et al. International consensus statement on an update of the classification criteria for definite antiphospholipid syndrome (APS).. J Thromb Haemost 2006; 4: 295-306.
14 Hankey G, Eikelboom J, van Bockxmeer F. et al. Inherited thrombophilia in ischemic stroke and its pathogenic subtypes.. Stroke 2001; 32: 1793-1799.
15 Carod-Artal FJ, Vilela Nunes S, Portugal D. Thrombophilia and patent foramen ovale in young stroke patients.. Neurologia 2006; 21: 710-716.
16 Sastry S, Riding G, Morris J. et al. Young Adult Myocardial Infarction and Ischemic Stroke: the role of paradoxical embolism and thrombophilia (The YAMIS Study).. J Am Coll Cardiol 2006; 48: 686-691.
17 Pezzini A, Del Zotto E, Magoni M. et al. Inherited thrombophilic disorders in young adults with ischemic stroke and patent foramen ovale.. Stroke 2003; 34: 28-33.
18 Karttunen V, Hiltunen L, Rasi V. et al. Factor V Leiden and prothrombin gene mutation may predispose to paradoxical embolism in subjects with patent foramen ovale.. Blood Coagul Fibrinolysis 2003; 14: 261-268.
19 Dodge SM, Hassell K, Anderson CA. et al. Antiphospholipid antibodies are common in patients referred for percutaneous patent foramen ovale closure.. Catheter Cardiovasc Interv 2004; 61: 123-127.
20 Belvis R, Santamaria A, Marti-Fabregas J. et al. Diagnostic yield of prothrombotic state studies in cryptogenic stroke.. Acta Neurol Scand 2006; 114: 250-253.
21 Cramer S. Patent foramen ovale and stroke: prognosis and treatment in young adults.. J Thromb Thrombolysis 2005; 20: 85-91.