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Thromb Haemost 2007; 98(06): 1215-1219
DOI: 10.1160/TH07-04-0247
Blood Coagulation, Fibrinolysis and Cellular Haemostasis
Schattauer GmbH

Role of haemorheological factors in patients with retinal vein occlusion

Francesco Sofi
1   Department of Medical and Surgical Critical Care, Thrombosis Centre, University of Florence, Azienda Ospedaliero-Universitaria Careggi, Florence, Italy; Center for the study at molecular and clinical level of chronic, degenerative and neoplastic diseases to DEvelop NOvel THErapies, University of Florence, Italy
,
Lucia Mannini
1   Department of Medical and Surgical Critical Care, Thrombosis Centre, University of Florence, Azienda Ospedaliero-Universitaria Careggi, Florence, Italy; Center for the study at molecular and clinical level of chronic, degenerative and neoplastic diseases to DEvelop NOvel THErapies, University of Florence, Italy
,
Rossella Marcucci
1   Department of Medical and Surgical Critical Care, Thrombosis Centre, University of Florence, Azienda Ospedaliero-Universitaria Careggi, Florence, Italy; Center for the study at molecular and clinical level of chronic, degenerative and neoplastic diseases to DEvelop NOvel THErapies, University of Florence, Italy
,
Paola Bolli
2   Don Carlo Gnocchi Foundation, IRCCS, Florence, Italy
,
Andrea Sodi
3   Department of Oto-Neuro-Ophthalmological Surgical Sciences, University of Florence, Azienda Ospedaliero-Universitaria Careggi, Florence, Italy
,
Barbara Giambene
3   Department of Oto-Neuro-Ophthalmological Surgical Sciences, University of Florence, Azienda Ospedaliero-Universitaria Careggi, Florence, Italy
,
Ugo Menchini
3   Department of Oto-Neuro-Ophthalmological Surgical Sciences, University of Florence, Azienda Ospedaliero-Universitaria Careggi, Florence, Italy
,
Gian Franco Gensini
1   Department of Medical and Surgical Critical Care, Thrombosis Centre, University of Florence, Azienda Ospedaliero-Universitaria Careggi, Florence, Italy; Center for the study at molecular and clinical level of chronic, degenerative and neoplastic diseases to DEvelop NOvel THErapies, University of Florence, Italy
2   Don Carlo Gnocchi Foundation, IRCCS, Florence, Italy
,
Rosanna Abbate
1   Department of Medical and Surgical Critical Care, Thrombosis Centre, University of Florence, Azienda Ospedaliero-Universitaria Careggi, Florence, Italy; Center for the study at molecular and clinical level of chronic, degenerative and neoplastic diseases to DEvelop NOvel THErapies, University of Florence, Italy
,
Domenico Prisco
1   Department of Medical and Surgical Critical Care, Thrombosis Centre, University of Florence, Azienda Ospedaliero-Universitaria Careggi, Florence, Italy; Center for the study at molecular and clinical level of chronic, degenerative and neoplastic diseases to DEvelop NOvel THErapies, University of Florence, Italy
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Publikationsverlauf

Received 04. April 2007

Accepted after revision 03. Oktober 2007

Publikationsdatum:
30. November 2017 (online)

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Summary

Retinal vein occlusion (RVO) is an important cause of permanent visual loss. Hyperviscosity, due to alterations of blood cells and plasma components, may play a role in the pathogenesis of RVO. Aim of this case-control study was to evaluate the possible association between haemorheology and RVO. In 180 RVO patients and in 180 healthy subjects comparable for age and gender we analysed the whole haemorheological profile: [whole blood viscosity (WBV), erythrocyte deformability index (DI), plasma viscosity (PLV), and fibrinogen]. WBV and PLV were measured using a rotational viscosimeter, whereas DI was measured by a microcomputer-assisted filtrometer. WBV at 0.512 sec-1 and 94.5 sec-1 shear rates as well as DI, but not PLV, were found to be significantly different in patients as compared to healthy subjects. At the logistic univariate analysis,a significant association between the highest tertiles of WBV at 94.5 sec-1 shear rate (OR:4.91,95%CI 2.95–8.17;p<0.0001),WBV at 0.512 sec-1 shear rate (OR: 2.31, 95%CI 1.42–3.77; p<0.0001), and the lowest tertile of DI (OR: 0.18, 95%CI 0.10–0.32; p<0.0001) and RVO was found. After adjustment for potential confounders,the highest tertiles of WBV at 0.512 sec-1 shear rate (OR: 3.23, 95%CI 1.39–7.48; p=0.006),WBV at 94.5 sec-1 shear rate (OR: 6.74, 95%CI 3.06–14.86; p<0.0001) and the lowest tertile of DI (OR:0.20,95%CI 0.09–0.44,p<0.0001) remained significantly associated with the disease. In conclusion,our data indicate that an alteration of haemorheological parameters may modulate the susceptibility to the RVO, by possibly helping to identify patients who may benefit from haemodilution.

Keywords

Blood viscosity - haemodilution - haemorheology - retinal vein occlusion
 

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