Von Willebrand factor: Looking back and looking forward

Zaverio M. Ruggeri

doi:10.1160/TH07-04-0279

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 2007; 98(01): 55-62
DOI: 10.1160/TH07-04-0279

Anniversary Issue Contribution

Schattauer GmbH

Von Willebrand factor: Looking back and looking forward

Zaverio M. Ruggeri

¹Roon Research Center for Arteriosclerosis and Thrombosis, Division of Blood Cell and Vascular Biology, Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, California, USA

› Author Affiliations

Abstract

Summary

Looking back at the last thirty years of studies on von Willebrand factor is a lesson on the importance of combining clinical observations with basic research. Most of what we know today originates from the perceptive evaluation of patients with congenital disorders of haemostasis such as haemophilia and von Willebrand disease. Understanding the causes of these diseases was akin to the current approach of using mutagenesis in animal models to get insights into the function of specific gene products. The information generated to date has been detailed and comprehensive, but looking into the future one sees that much remains to be done to understand how the role of von Willebrand factor and its primary platelet receptor, glycoprotein Ib, is integrated into the complex responses to vascular injury. Many challenges remain, along with the hope of translating the knowledge acquired into new and efficacious treatments for arterial thrombosis.

Keywords

Adhesion molecules - platelets - vascular biology - extracellular matrix - thrombin

Full Text

References

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