Potential implications of vascular wall resident endothelial progenitor cells

Süleyman Ergün; Derya Tilki; Hans-Peter Hohn; Ursula Gehling; Nerbil Kilic

doi:10.1160/TH07-04-0318

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 2007; 98(05): 930-939
DOI: 10.1160/TH07-04-0318

Theme Issue Article

Schattauer GmbH

Potential implications of vascular wall resident endothelial progenitor cells

Authors

Süleyman Ergün

¹Institute of Anatomy, University Hospital Essen, Essen, Germany
Derya Tilki

²Department of Urology, University Hospital Großhadern, Munich, Germany
Hans-Peter Hohn

¹Institute of Anatomy, University Hospital Essen, Essen, Germany
Ursula Gehling

³Department of Hepatobiliary and Transplant Surgery, University Hospital Hamburg-Eppendorf, Hamburg, Germany
Nerbil Kilic

⁴Department of Internal Medicine, Hematology/Oncology, University Hospital Hamburg-Eppendorf, Hamburg, Germany

Abstract

Summary

A rapidly increasing body of data suggests an essential role of endothelial progenitor cells (EPCs) in vascular regeneration, formation of new vessels in cardiovascular diseases and also in tumor vasculogenesis. Moreover, recent data obtained from clinical studies with anti-angiogenic drugs in tumor therapy or with pro-angiogenic stimuli in ischemic disorders implicate a predictive role of the number of EPCs circulating in the peripheral blood in monitoring of these diseases. However, there is still some controversial data regarding the relevance of the EPCs in vascular formation depending on models used and diseases studied. One of the essential prerequisites for a better understanding of the whole contribution of EPCs to vascular formation in adult, a process called postnatal vasculogenesis, is to identify their exact sources. We could recently discover the existence of EPCs in a distinct zone of the vascular wall of large and middle sized adult blood vessels and showed that these cells are capable to differentiate into mature endothelial cells, to form capillary sprouts in arterial ring assay and to build vasa vasorumlike structures within the vascular wall. They also can be mobilized very rapidly from the vascular wall by tumor cells. This review will discuss the functional implications of these vascular wall resident endothelial progenitor cells (VW-EPCs) in relation to those of EPCs circulating in peripheral blood or derived from the bone marrow in cardiovascular and neoplastic diseases.

Keywords

Postnatal vasculogenesis - angiogenesis - tumor - atherosclerosis - vascular adventitia

Full Text

References

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