Delayed-onset heparin-induced thrombocytopenia, venous thromboembolism, and cerebral venous thrombosis: A consequence of heparin “flushes”

Majed A. Refaai; Theodore E. Warkentin; Michael Axelson; Karen Matevosyan; Ravindra Sarode

doi:10.1160/TH07-06-0423

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 2007; 98(05): 1139-1140
DOI: 10.1160/TH07-06-0423

Case Report

Schattauer GmbH

Delayed-onset heparin-induced thrombocytopenia, venous thromboembolism, and cerebral venous thrombosis: A consequence of heparin “flushes”

Majed A. Refaai

¹Department of Pathology, The University of Texas Southwestern Medical Center, Dallas, Texas, USA

,

Theodore E. Warkentin

²Department of Pathology and Molecular Medicine and Department of Medicine, Michael G. DeGroote School of Medicine, McMaster University, Hamilton, Ontario, Canada

,

Michael Axelson

³Department of Internal Medicine, Division of Hematology/Oncology, The University of Texas Southwestern Medical Center, Dallas, Texas, USA

,

Karen Matevosyan

¹Department of Pathology, The University of Texas Southwestern Medical Center, Dallas, Texas, USA

,

Ravindra Sarode

¹Department of Pathology, The University of Texas Southwestern Medical Center, Dallas, Texas, USA

› Author Affiliations

Abstract

Full Text

References

References
1 Warkentin TE, Kelton JG. Temporal aspects of heparin- induced thrombocytopenia. N Engl J Med 2001; 344: 1286-1292.
2 Warkentin TE, Kelton JG. Delayed-onset heparininduced thrombocytopenia and thrombosis. Ann Intern Med 2001; 135: 502-506.
3 Rice L, Attisha WK, Drexler A. et al. Delayed-onset heparin-induced thrombocytopenia. Ann Intern Med 2002; 136: 210-215.
4 Warkentin TE, Bernstein RA. Delayed-onset heparin- induced thrombocytopenia and cerebral thrombosis after a single administration of unfractionated heparin. N Engl J Med 2003; 348: 1067-1069.
5 Heeger PS, Backstrom JT. Heparin flushes and thrombocytopenia. Ann Intern Med 1986; 105: 143.
6 Doty JR, Alving BM, McDonnell DE. et al. Heparin- associated thrombocytopenia in the neurosurgical patient. Neurosurgery 1986; 19: 69-72.
7 Ling E, Warkentin TE. Intraoperative heparin flushes and subsequent acute heparin-induced thrombocytopenia. Anesthesiology 1998; 89: 1567-1569.
8 Muslimani AA, Ricaurte B, Daw HA. Immune heparin- induced thrombocytopenia resulting from preceding exposure to heparin catheter flushes. Am J Hematol 2007; 82: 652-655.
9 Rauova L, Zhai L, Kowalska MA. et al. Role of platelet surface PF4 antigenic complexes in heparin-induced thrombocytopenia pathogenesis: diagnostic and therapeutic implications. Blood 2006; 107: 2346-2353.
10 Hong AP, Cook DJ, Sigouin CS. et al. Central venous catheters and upper-extremity deep-vein thrombosis complicating immune heparin-induced thrombocytopenia. Blood 2003; 101: 3049-3051.