The effects of exercise capacity and sedentary lifestyle on haemostasis among middle-aged women with coronary heart disease

Edit Nagy; Imre Janszky; Margita Eriksson-Berg; Faris Al-Khalili; Karin Schenck-Gustafsson

doi:10.1160/TH07-10-0650

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 2008; 100(05): 899-904
DOI: 10.1160/TH07-10-0650

Cardiovascular Biology and Cell Signalling

Schattauer GmbH

The effects of exercise capacity and sedentary lifestyle on haemostasis among middle-aged women with coronary heart disease

Edit Nagy

¹Karolinska Institutet, Division of Medicine, Cardiology Unit, Stockholm, Sweden

,

Imre Janszky

²Department of Public Health Sciences, Division of Preventive Medicine, Karolinska Institutet, Stockholm, Sweden

³Institute of Behavioural Sciences, Semmelweis University, Budapest, Hungary

,

Margita Eriksson-Berg

⁴Department of Emergency Medicine, Karolinska University Hospital, Solna, Stockholm, Sweden

,

Faris Al-Khalili

⁵Karolinska Institutet, Department of Clinical Sciences, Division of Cardiology, Danderyds University Hospital, Stockholm, Sweden

,

Karin Schenck-Gustafsson

¹Karolinska Institutet, Division of Medicine, Cardiology Unit, Stockholm, Sweden

› Author Affiliations

Abstract

Summary

Previous studies have established a link/relationship between haemostatic factors and increased risk of cardiovascular disease. In addition, physical conditioning is associated with lower coronary heart disease risk. The purpose of this study was to assess the association between physical exercise and haemostatic factors among middle-aged women surviving an acute coronary event. The Stockholm Female Coronary Risk Study included 292 women aged < 65 years, resident in the greater Stockholm area, who were hospitalized for an acute coronary syndrome. Extensive clinical screening including exercise testing, and blood tests were performed 3–6 months after the coronary event. Self-reported physical activity was assessed by a WHO questionnaire. Patients on warfarin treatment were excluded from our analyses. Haemostatic factors were generally higher among physically inactive patients when compared to physically active women in our univariate models. Exercise capacity had a statistically significant relationship with factor VII antigen (p=0.039) and vWFag (p=0.038) even in our multiadjusted analyses. Physical inactivity and poor physical fitness are associated with a potentially prothrombotic blood profile in middle aged women with coronary heart disease.

Keywords

Coagulation - fibrinolysis - exercise capacity - women - coronary artery disease

Full Text

References

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