RSS-Feed abonnieren
Bitte kopieren Sie die angezeigte URL und fügen sie dann in Ihren RSS-Reader ein.
https://www.thieme-connect.de/rss/thieme/de/10.1055-s-00035024.xml
PDF herunterladen
Thromb Haemost 2009; 101(01): 209-212
DOI: 10.1160/TH08-04-0224
DOI: 10.1160/TH08-04-0224
Letters to the Editor
Low absolute risk of venous and arterial thrombosis in hyperhomocysteinaemia – A prospective family cohort study in asymptomatic subjects
Financial support: By the Dutch Heart Foundation (Grant no: 99.187). The funder had no role in the design and conduct of the study, collection, management, analysis, and interpretation of the data; and preparation, review, or approval of the manuscript.
Weitere Informationen
Publikationsverlauf
Received:
09. April 2008
Accepted after major revision:
24. Oktober 2008
Publikationsdatum:
23. November 2017 (online)
-
References
- 1 McCully KS. Vascular pathology of homocysteinemia: implications for the pathogenesis of arteriosclerosis. Am J Pathol 1969; 56: 111-128.
- 2 The Homocysteine Studies Collaboration.. Homocysteine and risk of ischemic heart disease and stroke: a meta-analysis. J Am Med Assoc 2002; 288: 2015-2022.
- 3 den Heijer M, Rosendaal FR, Blom HJ. et al. Hyperhomocysteinemia and venous thrombosis: a meta-analysis. Thromb Haemost 1998; 80: 874-877.
- 4 Bonaa KH, Njolstad I, Ueland PM. et al. Homocysteine lowering and cardiovascular events after acute myocardial infarction. N Engl J Med 2006; 354: 1578-1588.
- 5 den Heijer M, Willems HP, Blom HJ. et al. Homocysteine lowering by B vitamins and the secondary prevention of deep vein thrombosis and pulmonary embolism: A randomized, placebo-controlled, double-blind trial. Blood 2007; 109: 139-144.
- 6 Lonn E, Yusuf S, Arnold MJ. et al. Homocysteine lowering with folic acid and B vitamins in vascular disease. N Engl J Med 2006; 354: 1567-1577.
- 7 Ray JG, Kearon C, Yi Q. et al. Homocysteine-lowering therapy and risk for venous thromboembolism: a randomized trial. Ann Intern Med 2007; 146: 761-767.
- 8 Lijfering WM, Coppens M, van de Poel MH. et al. The risk of venous and arterial thrombosis in hyperhomocysteinaemia is low and mainly depends on concomitant thrombophilic defects. Thromb Haemost 2007; 98: 457-463.
- 9 den Heijer M, Koster T, Blom HJ. et al. Hyperhomocysteinemia as a risk factor for deep-vein thrombosis. N Engl J Med 1996; 334: 759-762.
- 10 Lijfering WM, Veeger NJ, Brouwer JL. et al. Methionine-loading and random homocysteine tests have no added value in risk assessment for venous and arterial thrombosis. J Thromb Haemost 2007; 05: 614-616.
- 11 Keijzer MB, Verhoef P, Borm GF. et al. No added value of the methionine loading task in assessment for venous thrombosis and cardiovascular disease risk. Thromb Haemost 2006; 95: 380-385.
- 12 Martinelli I, Bucciarelli P, Zighetti ML. et al. Low risk of thrombosis in family members of patients with hyperhomocysteinaemia. Br J Haematol 2002; 117: 709-711.
- 13 Nordstrom M, Lindblad B, Bergqvist D. et al. A prospective study of the incidence of deep-vein thrombosis within a defined urban population. J Intern Med 1992; 232: 155-160.
- 14 Vasan RS, Benjamin EV, Sullivan LM. et al. The Burden of Increasing Worldwide Cardiovascular Disease. In: Fuster V, O’Rourke RA, Walsh RA, Poole-Wilson P. editors. Hurst’s The Heart. New York: McGraw-Hill; Medical Pub. Division 2007
- 15 Vaya A, Gomez I, Mira Y. et al. Homocysteine levels in patients with deep vein thrombosis lacking thrombophilic defects. Thromb Haemost 2008; 99: 1132-1134.