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Thromb Haemost 2009; 101(02): 284-289
DOI: 10.1160/TH08-05-0300
Review Article
Schattauer GmbH

The plasma membrane redox system in human platelet functions and platelet-leukocyte interactions

Domenico Del Principe
1   Department of Public Health and Cell Biology, University of Rome ‘Tor Vergata’, Italy
,
Gianluca Frega
1   Department of Public Health and Cell Biology, University of Rome ‘Tor Vergata’, Italy
,
Isabella Savini
2   Department of Experimental Medicine & Biochemical Sciences, University of Rome ‘Tor Vergata’, Italy
,
Valeria M. Catani
2   Department of Experimental Medicine & Biochemical Sciences, University of Rome ‘Tor Vergata’, Italy
,
Antonello Rossi
2   Department of Experimental Medicine & Biochemical Sciences, University of Rome ‘Tor Vergata’, Italy
,
Luciana Avigliano
2   Department of Experimental Medicine & Biochemical Sciences, University of Rome ‘Tor Vergata’, Italy
› Author AffiliationsFinancial support: This work was supported by grants from the Italian MIUR.
Further Information

Publication History

Received: 15 May 2008

Accepted after major revision: 30 January 2008

Publication Date:
23 November 2017 (online)

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Summary

The plasma membrane electron transport is crucial for blood coagulation and thrombosis, since reactive oxygen species and thiol changes, generated by plasma membrane redox reactions, modulate activation of platelets, as well as their interaction with leukocytes. Several antioxidants are linked to this system; thus, platelets are also able to counterbalance radical production and to regulate thrombus growth. Aim of this review is to give an update on the plasma membrane redox system in platelets, as well as on its role in platelet functions and leukocyte-platelet crosstalk.

Keywords

Platelets - plasma membrane redox system - NAD(P)H oxidase - ubiquinone - antioxidant vitamins
 

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