The plasma membrane redox system in human platelet functions and platelet-leukocyte interactions

Domenico Del Principe; Gianluca Frega; Isabella Savini; Valeria M. Catani; Antonello Rossi; Luciana Avigliano

doi:10.1160/TH08-05-0300

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 2009; 101(02): 284-289
DOI: 10.1160/TH08-05-0300

Review Article

Schattauer GmbH

The plasma membrane redox system in human platelet functions and platelet-leukocyte interactions

Domenico Del Principe

¹Department of Public Health and Cell Biology, University of Rome ‘Tor Vergata’, Italy

,

Gianluca Frega

¹Department of Public Health and Cell Biology, University of Rome ‘Tor Vergata’, Italy

,

Isabella Savini

²Department of Experimental Medicine & Biochemical Sciences, University of Rome ‘Tor Vergata’, Italy

,

Valeria M. Catani

²Department of Experimental Medicine & Biochemical Sciences, University of Rome ‘Tor Vergata’, Italy

,

Antonello Rossi

²Department of Experimental Medicine & Biochemical Sciences, University of Rome ‘Tor Vergata’, Italy

,

Luciana Avigliano

²Department of Experimental Medicine & Biochemical Sciences, University of Rome ‘Tor Vergata’, Italy

› Author Affiliations

Abstract

Summary

The plasma membrane electron transport is crucial for blood coagulation and thrombosis, since reactive oxygen species and thiol changes, generated by plasma membrane redox reactions, modulate activation of platelets, as well as their interaction with leukocytes. Several antioxidants are linked to this system; thus, platelets are also able to counterbalance radical production and to regulate thrombus growth. Aim of this review is to give an update on the plasma membrane redox system in platelets, as well as on its role in platelet functions and leukocyte-platelet crosstalk.

Keywords

Platelets - plasma membrane redox system - NAD(P)H oxidase - ubiquinone - antioxidant vitamins

Full Text

References

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