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Thromb Haemost 2008; 100(06): 1207-1208
DOI: 10.1160/TH08-05-0340
Letters to the Editor
Schattauer GmbH

Fresh frozen plasma does not reduce in vivo thrombin formation after neonatal cardiopulmonary bypass surgery

Satu Långström
1   Hospital for Children and Adolescents, University of Helsinki, Helsinki, Finland
,
Paula Rautiainen
2   Department of Anesthesia and Intensive Care, Hospital for Children and Adolescents, University of Helsinki, Helsinki, Finland
,
Leena Mildh
2   Department of Anesthesia and Intensive Care, Hospital for Children and Adolescents, University of Helsinki, Helsinki, Finland
,
Kaija Peltola
2   Department of Anesthesia and Intensive Care, Hospital for Children and Adolescents, University of Helsinki, Helsinki, Finland
,
Ulla Wartiovaara-Kautto
3   Helsinki University Central Hospital Laboratory Services (HUSLAB), Department of Clinical Chemistry, Laboratory of Hematology, University of Helsinki, Finland
,
Markku Heikinheimo
1   Hospital for Children and Adolescents, University of Helsinki, Helsinki, Finland
4   Department of Pediatrics, Washington University School of Medicine, St. Louis, Missouri, USA
,
Jari Petäjä
1   Hospital for Children and Adolescents, University of Helsinki, Helsinki, Finland
5   Department of Pediatrics, Jorvi Hospital, University of Helsinki, Espoo, Finland
› Author AffiliationsFinancial support: The study was supported by the Finnish Pediatric Research Foundation, the Helsinki University Hospital Research Funds, and the Lilly Foundation.
Further Information

Publication History

Received: 30 May 2008

Accepted after major revision: 25 September 2008

Publication Date:
23 November 2017 (online)

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  • References

  • 1 Williams GD, Bratton SL, Riley EC. et al. Coagulation tests during cardiopulmonary bypass correlate with blood loss in children undergoing cardiac surgery. J Cardiothorac Vasc Anesth 1999; 13: 398-404.
    CrossrefPubMedSearch in Google Scholar
  • 2 Petäjä J, Lundström U, Sairanen H. et al. Central venous thrombosis after cardiac operations in children. J Thorac Cardiovasc Surg 1996; 112: 883-889.
    CrossrefPubMedSearch in Google Scholar
  • 3 Raivio P, Kuitunen A, Suojaranta-Ylinen R. et al. Thrombin generation during reperfusion after cardiopulmonary bypass predicts postoperative myocardial damage in patients undergoing coronary artery bypass surgery. J Thromb Haemost 2006; 04: 1523-1527.
    CrossrefPubMedSearch in Google Scholar
  • 4 Hyytiäinen S, Syrjälä M, Fellman V. et al. Fresh frozen plasma reduces thrombin formation in newborn infants. J Thromb Haemost 2003; 01: 1189-1194.
    CrossrefPubMedSearch in Google Scholar
  • 5 Långström S, Rautiainen P, Mildh L. et al. Thrombin regulation in neonates undergoing cardiopulmonary bypass. Thromb Haemost 2008; 99: 791-792.
    Thieme ConnectPubMedSearch in Google Scholar
  • 6 De Jonge E, Levi M. Effects of different plasma substitutes on blood coagulation: A comparative review. Crit Care Med 2001; 29: 1261-1266.
    CrossrefPubMedSearch in Google Scholar
  • 7 Jormalainen M, Vento AE, Wartiovaara-Kautto U. et al. Recombinant hirudin enhances cardiac output and decreases systemic vascular resistance during reperfusion after cardiopulmonary bypass ina porcine model. J Thorac Cardiovasc Surg 2004; 128: 189-196.
    CrossrefPubMedSearch in Google Scholar
  • 8 Guzzetta NA, Miller BE, Todd K. et al. An evaluation of the effects of a standard heparin dose on thrombin inhibition during cardiopulmonary bypass in neonates. Anesth Analg 2005; 100: 1276-1282.
    CrossrefPubMedSearch in Google Scholar
  • 9 Mössinger H, Dietrich W, Braun SL. et al. Highdose aprotinin reduces activation of hemostasis, allogeneic blood requirement, and duration of postoperative ventilation in pediatric cardiac surgery. Ann Thorac Surg 2003; 75: 430-437.
    CrossrefPubMedSearch in Google Scholar
  • 10 Flaujac C, Pouard P, Boutouyrie P. et al. Platelet dysfunction after normothermic cardiopulmonary bypass in children: Effect of high-dose aprotinin. Thromb Haemost 2007; 98: 385-391.
    Thieme ConnectPubMedSearch in Google Scholar