Thrombosis and Haemostasis, Table of Contents Thromb Haemost 2008; 100(03): 377-378DOI: 10.1160/TH08-07-0450 Editorial Focus Schattauer GmbH Statin and endothelial cell-derived microparticles Shosaku Nomura 1 Division of Hematology, Kishiwada City Hospital, Osaka, Japan › Author Affiliations Recommend Article Abstract Buy Article Full Text References References 1 Nomura S, Ozaki Y, Ikeda Y. Function and role of microparticles in various clinical settings. Thromb Res. 2008 in press. 2 Morel O, Toti F, Hugel B. et al. Procoagulant microparticles: disrupting the vascular homeostasis equation?. Arterioscler Thromb Vasc Biol 2006; 26: 2594-2604. 3 Mallat Z, Benamer H, Hugel B. et al. Elevated levels of shed membrane microparticles with procoagulant potential in the peripheral circulating blood of patients with acute coronary syndromes. Circulation 2000; 101: 841-843. 4 Matsumoto N, Nomura S, Kamihata H. et al. Increased level of oxidized LDL-dependent monocyte-derived microparticles in acute coronary syndrome. Thromb Haemost 2004; 91: 146-154. 5 Chirinos JA, Heresi GA, Velasquez H. et al. Elevation of endothelial microparticles, platelets, and leukocyte activation in patients with venous thromboembolism. J Am Coll Cardiol 2005; 45: 1467-1471. 6 Weber A, Koppen HO, Schrör K. Platelet-derived microparticles stimulate coronary artery smooth muscle cell mitogenesis by a PDGF-independent mechanism. Thromb Res 2000; 98: 461-466. 7 Boulanger CM, Scoazec A, Ebrahimian T. et al. Circulating microparticles from patients with myocardial infarction cause endothelial dysfunction. Circulation 2001; 104: 2649-2652. 8 Biro E, Nieuwland R, Tak PP. et al. Activated coplement components and coplement activator molecules on the surface of cell-derived microparticles in patients with rheumatoid arthritis and healthy individuals. Ann Rheum Dis 2007; 66: 1085-1092. 9 Sapet C, Simoncini S, Loriod B. et al. Thrombin-induced endothelial microparticle generation: identification of a novel pathway involving ROCK-II activation by caspase-2. Blood 2006; 108: 1868-1876. 10 Boulanger CM, Amabile N, Guerin AP. et al. In vivo shear stress determines circulating levels of endothelial microparticles in end-stage renal disease. Hypertension 2007; 49: 902-908. 11 Kagawa H, Komiyama Y, Nakamura S. et al. Expression of functional tissue factor on small vesicles of lipopolysaccharide-stimulated human vascular endothelial cells. Thromb Res 1998; 91: 297-304. 12 Nomura S, Shouzu A, Omoto S. et al. Activated platelets and oxidized LDL induce endothelial membrane vesiculation: clinical significance of endothelial cell-derived microparticles in patients with type 2 diabetes. Clin Appl Thromb Hemost 2004; 10: 205-215. 13 Nomura S, Ishii K, Kanazawa S. et al. Significance of elevation in cell-derived microparticles after allogeneic stem cell transplantation: transient elevation of platelet-derived microparticles in TMA/TTP. Bone Marrow Transplant 2005; 36: 921-922. 14 Nomura S, Ishii K, Inami N. et al. Role of soluble tumor necrosis factor-related apoptosis-inducing ligand concentration after stem cell transplantation. Transplant Immunol 2007; 18: 115-121. 15 Nomura S, Ishii K, Inami N. et al. Evaluation of angiopoietin and cell-derived microparticles after stem cell transplantation. Biol Blood Marrow Transplant 2008; 14: 766-774. 16 Morel O, Ohlmann P, Epailly E. et al. Endothelial cell activation contributes to the release of procoagulant microparticles during acute cardiac allograft rejection. J Heart Lung Transplantation 2008; 27: 38-45. 17 Bakouboula B, Morel O, Faure A. et al. Procoagulant membrane microparticles correlate with the severity of pulmonary arterial hypertension. Am J Respir Crit Care Med 2008; 177: 536-543. 18 Croft KD, Beilin LJ, Vandongen R. et al. Leukocyte and platelet function and eicosanoid production in subjects with hypercholesterolemia. Atherosclerosis 1990; 83: 101-109. 19 Randomised trial of cholesterol lowering in 4444 patients with coronary heart disease: the Scandinavian Simvastatin Survival Study (4S). Lancet. 1994 344. 1383-1389. 20 Kaneta S, Satoh K, Kano S. et al. All hydrophobic HMG-CoA reductase inhibitors induce apoptotic death in rat pulmonary vein endothelial cells. Atherosclerosis 2003; 170: 237-243. 21 Feng C, Ye C, Liu X. et al. Beta4 integrin is involved in statin-induced endothelial cell death. Biochem Biophys Res Commun 2004; 323: 858-864. 22 Ferrara DE, Pierangeli SS. Diverse effects of statins on endothelial cells?. Thromb Haemost 2005; 93: 186-188. 23 Diamant M, Tushuizen ME, Abid-Hussein MN. et al. Simvastatin- induced endothelial cell detachment and microparticle release are prenylation dependent. Thromb Haemost 2008; 100: 489-497. 24 Hamilton KK, Hattori R, Esmon CT. et al. Complement proteins C5b-9 induce vesiculation of the endothelial plasma membrane and expose catalytic surface for assembly of the prothrombinase enzyme complex. J Biol Chem 1990; 265: 3809-3814. 25 Freyssinet JM. Cellular microparticles: what are they bad or good for?. J Thromb Haemost 2003; 01: 1655-1662. 26 Berckmans RJ, Nieuwland R, Boing AN. et al. Cellderived microparticles circulate in healthy humans and support low grade thrombin generation. Thromb Haemost 2001; 85: 639-646.