Download PDF
Thromb Haemost 2008; 100(05): 731-732
DOI: 10.1160/TH08-10-0646
Editorial Focus
Schattauer GmbH

A radical explanation for the effect of the HPA-1b polymorphism in platelet αIIbβ3-integrin?

Alison H. Goodall
1   Department of Cardiovascular Sciences, University of Leicester, Leicester, UK
› Author Affiliations
Further Information

Publication History

Received 07 October 2008

Accepted 07 October 2008

Publication Date:
22 November 2017 (online)

Also available at
    Permissions and Reprints

 

 

  • References

  • 1 Essex DW. The role of thiols and disulfides in platelet function. Antioxid Redox Signal 2004; 06: 736-746.
    CrossrefPubMedGoogle Scholar
  • 2 Weiss EJ, Bray PF, Tayback M. et al. A polymorphism of a platelet glycoprotein receptor is an inherited risk factor for coronary thrombosis. N Engl J Med 1996; 334: 1090-1094.
    CrossrefPubMedGoogle Scholar
  • 3 Vijayan KV, Bray PF. Molecular Mechanisms of prothrombotic risk due to genetic variations in platelet genes: Enhanced outside-in signaling through the Pro33 variant of integrin β3 . Exp Biol Med 2006; 231: 505-513.
    CrossrefPubMedGoogle Scholar
  • 4 Jones CI, Garner SF, Angenent W. et al. on behalf of the BLOODOMICS consortium. Mapping the platelet profile for functional genomic studies and demonstration of the effect size of the GP6 locus. J Thromb Haemost 2007; 05: 1756-1765.
    CrossrefPubMedGoogle Scholar
  • 5 Ball C, Vijayan KV, Nguyen T. et al. Glutathione regulates integrin αIIbβ3-mediated cell adhesion under flow conditions. Thromb Haemost 2008; 100: 857-863.
    Article in Thieme ConnectPubMedGoogle Scholar